Precipitating Antibodies

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General information

Where It's Done Who Does It How Long It Takes Discomfort/Pain
Doctor's office, commercial laboratory, or hospital. Doctor, nurse, or lab technician. Less than 5 minutes. Discomfort associated with drawing blood.

Results Ready When Special Equipment Risks/Complications Average Cost
1-2 weeks. Supplies for drawing blood. Negligible. $

Other names

Allergic lung serology.

Purpose

To diagnose farmer's lung disease and other lung disorders caused by an allergic reaction to inhaled fungi, molds, or other organic substances.

How it works

If an allergy is present, antibodies will be found in the serum part of the blood. When the serum is placed in a clear gel containing the suspected allergen, the antibodies will bind with the allergen and form a precipitate that clouds the gel.

Preparation

None.

Test procedure

Blood is drawn from your vein and sent to a laboratory for analysis.

After the test

Follow procedures for venous blood drawing.

Factors affecting results

The levels of precipitating antibodies may vary with fluctuations in the disease.

Interpretation

A cloudy, whitish band in the clear gel after the serum is added indicates that you may be allergic to the tested antigen. The test detects the antibodies only if they are present in large amounts.

Advantages

It entails no risk.

Disadvantages

There is a possibility of false-negatives and false-positives if test results aren't carefully correlated with history of disease.

The next step
  • A positive test in the presence of symptoms is considered definitive for diagnosis, and no further tests are necessary. However, your environment must be surveyed for sources of the allergen, e.g., moldy hay.
  • A negative test, if there is a history of symptoms, may be false, and the test may be repeated.

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