Precursor B-cell lymphoblastic leukemia
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Precursor B-cell lymphoblastic leukemia
| Precursor B-cell lymphoblastic leukemia | |
|---|---|
| Classification and external resources | |
| ICD-O: | M9836/3 |
| MeSH | D015452 |
Precursor B-cell lymphoblastic leukemia is a form of lymphoid leukemia, sometimes additionally classified as a lymphoma, as designated leukemia/lymphoma.
It consists of the following subtypes:[1]
- t(9;22)-BCR/ ABL
- t(v;11q23)-MLL rearrangement
- t(1;19)-E2A/PBX1
- t(12;21)-ETV/ CBFα
Molecular Mechanisms
One interesting model of precursor B ALL shows aberrant function of a single gene, namely Pax5, as capable to change phenotype of B cells toward precursor cells.[2][3]
References
- ^ Randolph TR (2004). "Advances in acute lymphoblastic leukemia". Clin Lab Sci 17 (4): 235–45. PMID 15559730. http://findarticles.com/p/articles/mi_qa3890/is_200410/ai_n9429273/pg_2.
- ^ Carotta S, Nutt SL (March 2008). "Losing B cell identity". Bioessays 30 (3): 203–7. doi:10.1002/bies.20725. PMID 18293359.
- ^ Den Boer ML, van Slegtenhorst M, De Menezes RX, et al. (February 2009). "A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study". Lancet Oncol. 10 (2): 125–34. doi:10.1016/S1470-2045(08)70339-5. PMC 2707020. PMID 19138562. http://linkinghub.elsevier.com/retrieve/pii/S1470-2045(08)70339-5.
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