Prednimustine

Prednimustine

Systematic (IUPAC) name
(11β)-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl 4-{4-[bis(2-chloroethyl)amino]phenyl}butanoate
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	29069-24-7 Y
ATC code	L01AA08
PubChem	CID 34457
UNII	9403SIO2S8 N
KEGG	C19512 Y
Synonyms	[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoate
Chemical data
Formula	C35H45Cl2NO6
Mol. mass	646.64 g/mol
N (what is this?)  (verify)

Prednimustine is a drug used in chemotherapy. It is the ester formed from two other drugs, prednisolone and chlorambucil.

It can be associated with myoclonus.^[1]

References

1. ^ Monnerat C, Gander M, Leyvraz S (January 1997). "A rare case of prednimustine-induced myoclonus". J. Natl. Cancer Inst. 89 (2): 173–4. doi:10.1093/jnci/89.2.173. PMID 8998190. http://jnci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=8998190. 

v t e Intracellular chemotherapeutic agents / antineoplastic agents (L01) SPs/MIs (M phase) Block microtubule assembly Vinca alkaloids (Vinblastine# Vincristine# Vinflunine§ Vindesine Vinorelbine) Block microtubule disassembly Taxanes (Cabazitaxel Docetaxel# Larotaxel Ortataxel† Paclitaxel# Tesetaxel) Epothilones (Ixabepilone) DNA replication inhibitor DNA precursors/ antimetabolites (S phase) Folic acid Dihydrofolate reductase inhibitor (Aminopterin Methotrexate Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Raltitrexed Pemetrexed) Purine Adenosine deaminase inhibitor (Pentostatin) Halogenated/ribonucleotide reductase inhibitors (Cladribine Clofarabine Fludarabine) Thiopurine (Thioguanine# Mercaptopurine#) Pyrimidine Thymidylate synthase inhibitor (Fluorouracil# Capecitabine Tegafur Carmofur Floxuridine) DNA polymerase inhibitor (Cytarabine#) Ribonucleotide reductase inhibitor (Gemcitabine) Hypomethylating agent (Azacitidine Decitabine) Deoxyribonucleotide Ribonucleotide reductase inhibitor (Hydroxycarbamide) Topoisomerase inhibitors (S phase) I Camptotheca (Camptothecin Topotecan Irinotecan Rubitecan‡ Belotecan) II Podophyllum (Etoposide# Teniposide) II+Intercalation Anthracyclines (Aclarubicin Daunorubicin# Doxorubicin# Epirubicin Idarubicin Amrubicin† Pirarubicin Valrubicin Zorubicin) Anthracenediones (Mitoxantrone Pixantrone) Crosslinking of DNA (CCNS) Alkylating Nitrogen mustards: Mechlorethamine Cyclophosphamide# (Ifosfamide Trofosfamide) Chlorambucil# (Melphalan Prednimustine) Bendamustine Uramustine Estramustine Nitrosoureas: Carmustine Lomustine (Semustine) Fotemustine Nimustine Ranimustine Streptozocin Alkyl sulfonates: Busulfan (Mannosulfan Treosulfan) Aziridines: Carboquone ThioTEPA Triaziquone Triethylenemelamine Alkylating-like Platinum (Carboplatin Cisplatin Nedaplatin Oxaliplatin Triplatin tetranitrate Satraplatin) Nonclassical Hydrazines (Procarbazine#) Triazenes (Dacarbazine# Temozolomide) Altretamine Mitobronitol Intercalation Streptomyces (Actinomycin# Bleomycin# Mitomycin Plicamycin) Photosensitizers/PDT Aminolevulinic acid / Methyl aminolevulinate Efaproxiral Porphyrin derivatives (Porfimer sodium Talaporfin Temoporfin Verteporfin) Other Enzyme inhibitors FI (Tipifarnib) CDK inhibitors (Alvocidib Seliciclib) PrI (Bortezomib) PhI (Anagrelide) IMPDI (Tiazofurine) LI (Masoprocol) PARP inhibitor (Olaparib) HDAC (Panobinostat Vorinostat Romidepsin) Receptor antagonists ERA (Atrasentan) Retinoid X receptor (Bexarotene) Sex steroid (Testolactone) Other/ungrouped Amsacrine Trabectedin Retinoids (Alitretinoin Tretinoin) Arsenic trioxide Asparagine depleters (Asparaginase#/Pegaspargase) Celecoxib Demecolcine Elesclomol§ Elsamitrucin Etoglucid Lonidamine HAMLET (human alpha-lactalbumin made lethal to tumor cells) Lucanthone Mitoguazone Mitotane Oblimersen† Omacetaxine mepesuccinate§ mTOR inhibitors (Everolimus Temsirolimus) #WHO-EM ‡Withdrawn from market Clinical trials: †Phase III §Never to phase III M: NEO tsoc, mrkr tumr, epon, para drug (L1i/1e/V03)

v t e Corticosteroids – glucocorticoids and mineralocorticoids (H02) (also A07EA, C05AA, D07, D10AA, R01AD, R03BA, S01BA, S02B, and S03B) Mineralocorticoids (3-one, 4-ene, no FG at 16) Pregnenedione: ALDOSTERONE 11-DEOXYCORTICOSTERONE HALOGENATED AT 9: Fludrocortisone Glucocorticoids (3-one, 4-ene, 11-FG, 17-hydroxy) Pregnene CORTISONE Pregnenedione (+20-one) HYDROCORTISONE/CORTISOL# (Hydrocortisone aceponate Hydrocortisone buteprate Hydrocortisone butyrate) Budesonide Ciclesonide Deflazacort Medrysone Tixocortol HALOGENATED AT 6: Cloprednol HALOGENATED, WITH FG AT 16: Halcinonide Pregnadiene (+1-ene) Rimexolone HALOGENATED, WITH FG AT 16: Flunisolide Triamcinolone Amcinonide Fluocinolone acetonide (Fluocinonide) Pregnadienediol (+21-hydroxy) Prednisone (Meprednisone) HALOGENATED AT 9: Fluorometholone HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone Diflucortolone Fluocortin) Desoximetasone Pregnadienetriol (+11-hydroxy) Prednisolone# (Methylprednisolone Methylprednisolone aceponate Prednicarbate Prednylidene) Desonide HALOGENATED: Fluprednisolone (Difluprednate Fluperolone) HALOGENATED, WITH FG AT 16: Dexamethasone# Betamethasone (Clobetasol Clobetasone Diflorasone Halometasone Ulobetasol) Beclometasone Paramethasone Alclometasone Fluclorolone acetonide Flumetasone Fluprednidene Pregnatriene (+2-ene) Cortivazol Androstene HALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate Fluticasone furoate) Other/ungrouped HALOGENATED: Loteprednol HALOGENATED, WITH FG AT 16: Fludroxycortide Formocortal Mometasone furoate Aldosterone antagonists Spironolactone Eplerenone Potassium canrenoate Canrenone Synthesis modifiers Trilostane Carbenoxolone Aminoglutethimide Metyrapone #WHO-EM ‡Withdrawn from market Clinical trials: †Phase III §Never to phase III M: END anat/phys/devp/horm noco(d)/cong/tumr, sysi/epon proc, drug (A10/H1/H2/H3/H5)

v t e Glucocorticoids Receptor GR Agonists: Acrocinonide Alclometasone Amcinafal Amcinafide Amcinonide Amebucort Amelometasone Amicinonide Anecortave Beclometasone Beclometasone dipropionate Betamethasone Betamethasone acibutate Betamethasone dipropionate Budesonide Butixocort Chloroprednisone Ciclesonide Cicortonide Ciprocinonide Clobetasol Clobetasol propionate Clobetasone Clocortolone Cloprednol Cloticasone Cormetasone Corticosterone Cortisone Cortisuzol Cortivazol Cortodoxone Deflazacort Deoxycorticosterone Deprodone Descinolone Desonide Desoximetasone Desoxycortone Dexbudesonide Dexamethasone Dexamethasone acefurate Dexamethasone cipecilate Dexamethasone isonicotinate Dichlorisone Diflorasone Difluocortolone Difluocortolone valerate Difluprednate Domoprednate Doxibetasol Drocinonide Etiprednol dicloacetate Fluazacort Fluclorolone Fluclorolone/Flucloronide Fludrocortisone Fludroxycortide Flumoxonide Flumetasone Flunisolide Fluocinolone Fluocinolone acetonide Fluocinonide Fluocortin Fluocortolone Fluorometholone Fluperolone Fluperolone acetate Fluprednidene Fluprednidene acetate Fluprednisolone Fluticasone Fluticasone furoate Fluticasone propionate Formocortal Halcinonide Halocortolone Halometasone Halopredone Hydrocortamate Hydrocortisone/Cortisol Hydrocortisone aceponate Hydrocortisone buteprate Hydrocortisone-17-butyrate Hydrocortisone-21-butyrate Icometasone enbutate Isoflupredone Isoprednidene Itrocinonide Locicortolone dicibate Loteprednol Mazipredone Meclorisone Medrysone Meprednisone Methylprednisolone Methylprednisolone aceponate Methylprednisolone suleptanate Mometasone Mometasone furoate Naflocort Nicocortonide Nivacortol Oxisopred Paramethasone Prednazate Prednazoline Prednicarbate Prednimustine Prednisolamate Prednisolone Prednisolone steaglate Prednisone Prednylidene Procinonide Resocortol Rimexolone Rofleponide Timobesone Tipredane Tixocortol Tixocortol pivalate Tralonide Triamcinolone Triamcinolone acetonide Triamcinolone benetonide Triamcinolone furetonide Triamcinolone hexacetonide Triclonide Ulobetasol/Halobetasol Mixed (SEGRAs): Mapracorat Antagonists: Algepristone Asoprisinil 17-Hydroxyprogesterone Ketoconazole Lilopristone Mifepristone Onapristone Org 34850 PCN Pregnenolone Progesterone Telapristone Toripristone Ulipristal acetate Enzyme (inhibitors) 20,22-Desmolase 22-ABC 3,3′-Dimethoxybenzidine 3-Methoxybenzidine Aminoglutethimide Cyanoketone Danazol Etomidate Mitotane Trilostane 17α-Hydroxylase, 17,20-Lyase 22-ABC 22-Oxime Abiraterone Bifonazole Clotrimazole Cyanoketone Cyproterone Danazol Desogestrel Econazole Galeterone Gestrinone Isoconazole Ketoconazole L-39 Levonorgestrel Liarozole LY-207,320 MDL-27,302 Miconazole Mifepristone Norethisterone Orteronel Pioglitazone Rosiglitazone Spironolactone Stanozolol SU-10,603 Tioconazole TGF-β Troglitazone VN/87-1 YM116 3β-HSD 4-MA Azastene Cyanoketone Danazol Desogestrel Epostane Genistein Gestrinone Levonorgestrel Medroxyprogesterone Medroxyprogesterone acetate Metyrapone Norethisterone Oxymetholone Pioglitazone Rosiglitazone Trilostane Troglitazone 21-Hydroxylase Aminoglutethimide Amphenone B Bifonazole Clotrimazole Diazepam Econazole Genistein Isoconazole Ketoconazole Metyrapone Miconazole Midazolam Tioconazole Other Endogenous Glucocorticoids: Corticosterone Cortisone Cortodoxone/Deoxycortisol Hydrocortisone/Cortisol Antiglucocorticoids: 17-Hydroxyprogesterone Deoxycorticosterone Pregnenolone Progesterone Precursors: Cholesterol 22R-Hydroxycholesterol 20α,22R-Dihydroxycholesterol Pregnenolone 17-Hydroxypregnenolone 17-Hydroxyprogesterone Progesterone Deoxycorticosterone Indirect ACTH/Corticotropin CRH DHEA DHEA sulfate Plasma proteins (Transcortin, Albumin) Procedures Adrenalectomy Hypophysectomy

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