Prickle cell

Prickle Cells Drawing - Artist: Sandy G Phillips-Long

Prickle cells are keratin producing epidermal cells owing their prickly appearance to their numerous intracellular connections. They make up the spinosum layer (prickly layer) of the epidermis and provide a continuous net-like layer of protection for underlying tissue. They are susceptible to mutations caused by sunlight and can become malignant.

Histologic image showing a section of epidermis. Stratum spinosum labeled slightly below center.

Location

Prickle cells are found in the superficial layers of the skin (integumentary system). They lie above the basale layer (basal layer) and below the granulosum layer (granular layer) of the epidermis. The prickle layer is also known as the spinosum layer. The prickle layer’s cells are arranged several layers thick to form a net-like covering.^[1]

Origin

Prickle cells originate through mitosis in the basal layer (also known as the germinative layer). They are pushed upward into the prickle layer (spinosum layer) by the continuous formation of new cells in the basal layer.^[2] They reach the outmost layer of the skin as flattened dead flaking skin cells we shed daily. The journey from origin to shed takes 25 to 45 days.^[1]

Function

Prickle cells serve “as a physical and biological barrier to the environment, preventing penetration by irritants and allergens and loss of water while maintaining internal homeostasis.^[3] They accomplish this in two ways. First, they are keratinocytes (keratin cells) whose primary function is to produce keratin, a strong structural protein. The keratin accumulates within each prickle cell as it moves upward through the epidermis layers, until the cell is almost completely filled with hardening keratin (keratinisation).^[3] Second, the cells are bound together across their cytoplasm by keratin filaments that form cell to cell connections (desmosomes).^[1]

Cancer

Prickle cell carcinoma (spinocellular carcinoma) is relatively common in people over age 60, with fair skin, and a history of longer term sun exposure. It is not as commonly known as other skin cancers because it is less likely to metastasize, but can be just as deadly if left untreated.^[4]

See Also

Spinosum Layer

References

1. ^ ^{a b c} Marieb, Elaine N. (2003). Human Anatomy & Physiology, Sixth Edition. Prentice Hall College Div. pp. 152-155. ISBN 0-8057-1693-9. 
2. ^ Bensouilah, Janetta (November 2006). Aromadermatology: Aromatherapy in the Treatment and Care of Common Skin Conditions. Blackwell Publishers. pp. 3. ISBN 1857757750. 
3. ^ ^{a b} Lawton, MSc,RGN, OND, ENB393, RN, Sandra (October 3, 2006). "Anatomy and function of the skin - Part 2 - The epidermis". NursingTimes.net 102 (32): 28. http://www.nursingtimes.net/nursing-practice-clinical-research/anatomy-and-function-of-the-skin-part-2-the-epidermis/201108.article. Retrieved April 7, 2012. 
4. ^ Institute for Dermopharmacy GmbH (June, 2003). "New Insights Regarding Light Skin Carcinoma:". DermoTopics Newsletter (1). http://www.dermotopics.de/english/issue_1_03_e/licht_1_03_e.htm. Retrieved March 15, 2012. 

This cell biology article is a stub. You can help Wikipedia by expanding it. v t e