Profumo may refer to
- Alessandro Profumo (b. 1957), Italian banker, the CEO of the Gruppo Unicredito
- Francesco Profumo (b. 1953), Dean of the Engineering Faculty of the Politecnico di Torino
- Baron Profumo of the Kingdom of Sardinia
- Albert Profumo (1879 - 1940), English barrister and 4th Baron Profumo
- John Profumo (1915 – 2006), British politician and 5th Baron Profumo
- Profumo Affair, 1963 British political scandal
- David Profumo (b. 1955), English novelist and 6th Baron Profumo
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