proguanil hydrochloride

A drug used, usually in combination with chloroquine, for the prevention of malaria. It is also used in combination with atovaquone for the treatment of falciparum malaria and for the prevention of this in areas where there is resistance to melfloquine or chloroquine. Proguanil is available as tablets.

Side effects:
these are rare, but may include mild stomach upsets and diarrhoea and, occasionally, mouth ulcers and soreness, rashes, and hair loss.

Precautions:
proguanil should be used with caution in people with impaired kidney function. Pregnant women should take folic acid supplements.

Interactions with other drugs:

Riamet: should not be taken with proguanil.
Warfarin: the anticoagulant effect of this drug may be enhanced.

Proprietary preparations:
Paludrine (pharmacy medicine); Malarone and Malarone Paediatric (combined with atovaquone; prescription only medicine); Paludrine/Avloclor (packaged with chloroquine; pharmacy medicine).

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