Proinflammatory cytokine

A proinflammatory cytokine is a cytokine which promotes systemic inflammation.

Examples include IL-1^[1] and TNF alpha.^[2]

References

1. ^ Dinarello CA (August 2000). "Proinflammatory cytokines". Chest 118 (2): 503–8. doi:10.1378/chest.118.2.503. PMID 10936147. http://www.chestjournal.org/cgi/pmidlookup?view=long&pmid=10936147. 
2. ^ Cheung CY, Poon LL, Lau AS, et al. (December 2002). "Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?". Lancet 360 (9348): 1831–7. doi:10.1016/S0140-6736(02)11772-7. PMID 12480361. http://linkinghub.elsevier.com/retrieve/pii/S0140673602117727. 

v t e Cell signaling: cytokines By family Chemokine CCL CCL1 · CCL2/MCP-1 · CCL3/MIP-1α · CCL4/MIP-1β · CCL5/RANTES · CCL6 · CCL7 · CCL8 · CCL9 · CCL11 · CCL12 · CCL13 · CCL14 · CCL15 · CCL16 · CCL17 · CCL18 · CCL19 · CCL20 · CCL21 · CCL22 · CCL23 · CCL24 · CCL25 · CCL26 · CCL27 · CCL28 CXCL CXCL1/KC · CXCL2 · CXCL3 · CXCL4 · CXCL5 · CXCL6 · CXCL7 · CXCL8/IL8 · CXCL9 · CXCL10 · CXCL11 · CXCL12 · CXCL13 · CXCL14 · CXCL15 · CXCL16 · CXCL17 CX3CL CX3CL1 XCL XCL1 · XCL2 TNF TNFA · Lymphotoxin (TNFB/LTA, TNFC/LTB) · TNFSF4 · TNFSF5/CD40LG · TNFSF6 · TNFSF7 · TNFSF8 · TNFSF9 · TNFSF10 · TNFSF11 · TNFSF13B · EDA Interleukin Type I (grouped by receptor subunit) γ-chain IL2/IL15 · IL4/IL13 · IL7 · IL9 · IL21 β-chain IL3 · IL5 · GM-CSF IL6 like/gp130 IL6  · IL11 · IL27 · IL30 · IL31 (+non IL OSM, LIF, CNTF, CTF1) IL-12 family/IL12RB1 IL12 · IL23 · IL27 · IL35 Other IL14 · IL16 · IL32  · IL34 Type II IL-10 family IL10/IL22 · IL19 · IL20 · IL24 · IL26 · Interferon type III (IL28/IFNL2+3 · IL29/IFNL1) Interferon I IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, IFNK, IFNW1 II IFNG Ig superfamily IL-1 family: IL1A/IL1F1 · IL1B/IL1F2 · 1Ra/IL1F3 · IL1F5 · IL1F6 · IL1F7 · IL1F8 · IL1F9 · IL1F10 · 33/IL1F11  · 18/IL1G IL-17 family IL17/IL25 (IL17A) Other Hematopoietic (KITLG, Colony-stimulating factor) · SPP1 By function/ cell proinflammatory cytokine (IL1, TNFA) Monokine · Lymphokine (Th1 (IFNG and TNFB) · Th2 (IL4, IL5, IL6, IL10, IL13) ) B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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