Prokineticin receptor 2
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Prokineticin receptor 2
| Prokineticin receptor 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | PROKR2; GPR73L1; GPR73b; GPRg2; KAL3; PKR2; dJ680N4.3 | ||||||||||||
| External IDs | OMIM: 607123 MGI: 2181363 HomoloGene: 16368 IUPHAR: PKR2 GeneCards: PROKR2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 128674 | 246313 | |||||||||||
| Ensembl | ENSG00000101292 | ENSMUSG00000050558 | |||||||||||
| UniProt | Q8NFJ6 | Q6GTF8 | |||||||||||
| RefSeq (mRNA) | NM_144773 | NM_144944.3 | |||||||||||
| RefSeq (protein) | NP_658986 | NP_659193.3 | |||||||||||
| Location (UCSC) | Chr 20: 5.28 – 5.3 Mb |
Chr 2: 132.16 – 132.21 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Prokineticin receptor 2 (PKR2), in a G-protein coupled receptor encoded by the PROKR2 gene in humans.[1]
Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins.[1]
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Contents
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See also
References
External links
- GeneReviews/NCBI/NIH/UW entry on Kallmann syndrome
- "Prokineticin Receptors: PKR2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3017.
Further reading
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Lin DC, Bullock CM, Ehlert FJ, et al. (2002). "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor.". J. Biol. Chem. 277 (22): 19276–80. doi:10.1074/jbc.M202139200. PMID 11886876.
- Soga T, Matsumoto S, Oda T, et al. (2003). "Molecular cloning and characterization of prokineticin receptors.". Biochim. Biophys. Acta 1579 (2–3): 173–9. PMID 12427552.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Battersby S, Critchley HO, Morgan K, et al. (2004). "Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle". J. Clin. Endocrinol. Metab. 89 (5): 2463–9. doi:10.1210/jc.2003-032012. PMID 15126578.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Pasquali D, Rossi V, Staibano S, et al. (2006). "The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy". Endocrinology 147 (9): 4245–51. doi:10.1210/en.2006-0614. PMID 16763065.
- Dodé C, Teixeira L, Levilliers J, et al. (2006). "Kallmann Syndrome: Mutations in the Genes Encoding Prokineticin-2 and Prokineticin Receptor-2". PLoS Genet. 2 (10): e175. doi:10.1371/journal.pgen.0020175. PMC 1617130. PMID 17054399. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1617130.
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