Prolactin receptor
Oxford Dictionary of Biochemistry:
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prolactin receptor
a membrane protein of the cytokine receptor family. The prolactin receptor is associated with a small protein calcyclin.
| prolactin, prokaryote, prokaryosis | |
| prolamin, prolate, prolidase |
Wikipedia on Answers.com:
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Prolactin receptor
| prolactin receptor | |
|---|---|
| Identifiers | |
| Symbol | PRLR |
| Entrez | 5618 |
| HUGO | 9446 |
| OMIM | 176761 |
| PDB | 1RW5 |
| RefSeq | NM_000949 |
| UniProt | P16471 |
| Other data | |
| Locus | Chr. 5 p13-p12 |
The prolactin receptor—encoded by a gene on Chromosome 5p13-14—interacts with the prolactin molecule as a transmembrane receptor.
Thus it contains an extracellular region that binds prolactin, a transmembrane region, and a cytoplasmatic region.
The receptor is a cytokine receptor[1], and second messenger cascades include the JAK-STAT pathway, JAK-RUSH pathway [2][3], Ras-Raf-MAPK, and PI-3K [4].
There may be variation among different tissue prolactin receptors[5].
References
- ^ Prolactin: The multi-faceted potentiator of mammary growth and function. Trott JF, Schennink A, Petrie WK, Manjarin R, Vanklompenberg MK, Hovey RC. J Anim Sci. 2011 Dec 28.
- ^ Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling. Helmer RA, Panchoo M, Dertien JS, Bhakta SM, Hewetson A, Chilton BS. Mol Cell Endocrinol. 2010 Aug 30;325(1-2):143-9.
- ^ Prolactin induces Jak2 phosphorylation of RUSHY195. Helmer RA, Dertien JS, Chilton BS. Mol Cell Endocrinol. 2011 May 16;338(1-2):79-83.
- ^ The role of prolactin in mammary carcinoma. Clevenger CV, Furth PA, Hankinson SE, Schuler LA. Endocr Rev. 2003 Feb;24(1):1-27.
- ^ Impact of prolactin receptor isoforms on reproduction. Binart N, Bachelot A, Bouilly J. Trends Endocrinol Metab. 2010 Jun;21(6):362-8.
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Oxford Dictionary of Biochemistry
Oxford University Press. Oxford Dictionary of Biochemistry and Molecular Biology © 1997, 2000, 2006 All rights reserved.
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