| prolactin, prokaryote, prokaryosis | |
| prolamin, prolate, prolidase |
| prolactin receptor | |
|---|---|
| Identifiers | |
| Symbol | PRLR |
| Entrez | 5618 |
| HUGO | 9446 |
| OMIM | 176761 |
| PDB | 1RW5 |
| RefSeq | NM_000949 |
| UniProt | P16471 |
| Other data | |
| Locus | Chr. 5 p13-p12 |
The prolactin receptor—encoded by a gene on Chromosome 5p13-14—interacts with the prolactin molecule as a transmembrane receptor.
Thus it contains an extracellular region that binds prolactin, a transmembrane region, and a cytoplasmatic region.
The receptor is a cytokine receptor[1], and second messenger cascades include the JAK-STAT pathway, JAK-RUSH pathway [2][3], Ras-Raf-MAPK, and PI-3K [4].
There may be variation among different tissue prolactin receptors[5].
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