Protein-bound paclitaxel
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Protein-bound paclitaxel
| Combination of | |
|---|---|
| Paclitaxel | mitotic inhibitor |
| Albumin | delivery vehicle |
| Clinical data | |
| Trade names | Abraxane |
| AHFS/Drugs.com | FDA Professional Drug Information |
| Pregnancy cat. | ? |
| Legal status | ℞-only (US) |
| Routes | IV |
| Identifiers | |
| ATC code | ? |
 (what is this?) (verify) |
|
Protein-bound paclitaxel is an injectable formulation of paclitaxel, a mitotic inhibitor drug used in the treatment of breast cancer.[1] In this formulation, paclitaxel is bonded to albumin as a delivery vehicle. It is sold in the United States under the trade name Abraxane by Abraxis BioScience.[2]
This treatment was approved by the Food and Drug Administration in January 2005 and the European Medicines Agency in January 2008 for breast cancer cases where cancer did not respond to other chemotherapy or has relapsed.[3]
Abraxane is a first in its class of drugs using nanoparticle albumin bound (nab) technology platform.[4]
In June 2010, positive results were published from a phase III trial in first-line non-small-cell lung cancer (NSCLC) when compared with Taxol (solvent-based paclitaxel).[5]
Total revenue from the sales of Abraxane for 2009 were $314.5 million.[5]
In 2010, Abraxis was acquired by Celgene, who now market Abraxane.[6]
References
- ^ "Definition of "protein-bound paclitaxel"". National Cancer Institute Dictionary of Cancer Terms. http://www.cancer.gov/Templates/db_alpha.aspx?CdrID=507751.
- ^ "Paclitaxel Albumin-stabilized Nanoparticle Formulation". National Cancer Institute Drug Information. http://www.cancer.gov/cancertopics/druginfo/nanoparticlepaclitaxel.
- ^ "FDA Approval for Nanoparticle Paclitaxel". National Cancer Institute Drug Information. http://www.cancer.gov/cancertopics/druginfo/fda-nanoparticle-paclitaxel.
- ^ nab Technology
- ^ a b "Abraxis Reports Phase III Success with Abraxane in First-Line NSCLC". 2010. http://www.genengnews.com/gen-news-highlights/abraxis-reports-phase-iii-success-with-abraxane-in-first-line-nsclc/81243495/.
- ^ Celgene Completes Acquisition of Abraxis
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