Protein C inhibitor (PCI, SERPINA5) is a serine protease inhibitor (serpin) which limits the expression of protein C.
Interactions
Protein C inhibitor has been shown to interact with Prostate specific antigen,[1][2] Protein C[3][4] and PLAU.[5][3]
See also
Further reading
- Suzuki K, Hayashi T (2000). "cis-elements required for expression of human protein C inhibitor gene in HepG2 cells and its androgen-dependent expression in rat reproductive organs.". Semin. Thromb. Hemost. 26 (1): 75–83. doi:10.1055/s-2000-9807. PMID 10805286.
- Yasuda T, Nadano D, Iida R, et al. (1992). "Discovery of a genetic polymorphism of human plasma protein C inhibitor (PCI): genetic survey utilizing isoelectric focusing followed by immunoblotting, immunological and biochemical characterization.". Hum. Genet. 89 (3): 265–9. doi:10.1007/BF00220537. PMID 1318261.
- Laurell M, Christensson A, Abrahamsson PA, et al. (1992). "Protein C inhibitor in human body fluids. Seminal plasma is rich in inhibitor antigen deriving from cells throughout the male reproductive system.". J. Clin. Invest. 89 (4): 1094–101. doi:10.1172/JCI115689. PMID 1372913.
- Meijers JC, Chung DW (1991). "Organization of the gene coding for human protein C inhibitor (plasminogen activator inhibitor-3). Assignment of the gene to chromosome 14.". J. Biol. Chem. 266 (23): 15028–34. PMID 1714450.
- Kuhn LA, Griffin JH, Fisher CL, et al. (1990). "Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor.". Proc. Natl. Acad. Sci. U.S.A. 87 (21): 8506–10. doi:10.1073/pnas.87.21.8506. PMID 2172989.
- Meijers JC, Chung DW (1990). "Evidence for a glycine residue at position 316 in human protein C inhibitor.". Thromb. Res. 59 (2): 389–93. doi:10.1016/0049-3848(90)90142-Y. PMID 2173165.
- España F, Berrettini M, Griffin JH (1989). "Purification and characterization of plasma protein C inhibitor.". Thromb. Res. 55 (3): 369–84. doi:10.1016/0049-3848(89)90069-8. PMID 2551064.
- Laurell M, Stenflo J (1990). "Protein C inhibitor from human plasma: characterization of native and cleaved inhibitor and demonstration of inhibitor complexes with plasma kallikrein.". Thromb. Haemost. 62 (3): 885–91. PMID 2556811.
- Geiger M, Huber K, Wojta J, et al. (1989). "Complex formation between urokinase and plasma protein C inhibitor in vitro and in vivo.". Blood 74 (2): 722–8. PMID 2752144.
- Suzuki K, Deyashiki Y, Nishioka J, et al. (1987). "Characterization of a cDNA for human protein C inhibitor. A new member of the plasma serine protease inhibitor superfamily.". J. Biol. Chem. 262 (2): 611–6. PMID 3027058.
- Suzuki K, Nishioka J, Hashimoto S (1983). "Protein C inhibitor. Purification from human plasma and characterization.". J. Biol. Chem. 258 (1): 163–8. PMID 6294098.
- Christensson A, Lilja H (1994). "Complex formation between protein C inhibitor and prostate-specific antigen in vitro and in human semen.". Eur. J. Biochem. 220 (1): 45–53. doi:10.1111/j.1432-1033.1994.tb18597.x. PMID 7509746.
- Zheng X, Geiger M, Ecke S, et al. (1994). "Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa.". Am. J. Physiol. 267 (2 Pt 1): C466–72. PMID 7521127.
- Radtke KP, Fernández JA, Greengard JS, et al. (1994). "Protein C inhibitor is expressed in tubular cells of human kidney.". J. Clin. Invest. 94 (5): 2117–24. doi:10.1172/JCI117566. PMID 7525654.
- Hayashi S (1994). "Urinary protein C inhibitor binding region in the B beta-chain of human fibrinogen.". Blood Coagul. Fibrinolysis 4 (6): 921–6. doi:10.1097/00001721-199304060-00009. PMID 8148485.
- Hayashi T, Suzuki K (1994). "Gene organization of human protein C inhibitor, a member of SERPIN family proteins encoded in five exons.". Int. J. Hematol. 58 (3): 213–24. PMID 8148499.
- Billingsley GD, Walter MA, Hammond GL, Cox DW (1993). "Physical mapping of four serpin genes: alpha 1-antitrypsin, alpha 1-antichymotrypsin, corticosteroid-binding globulin, and protein C inhibitor, within a 280-kb region on chromosome I4q32.1.". Am. J. Hum. Genet. 52 (2): 343–53. PMID 8381582.
- Hayashi S, Yamada K (1993). "Binding of urinary protein C inhibitor to fibrin(ogen) and its binding mechanism.". Blood Coagul. Fibrinolysis 4 (1): 153–8. doi:10.1097/00001721-199304010-00027. PMID 8384496.
- Moore A, Penfold LM, Johnson JL, et al. (1993). "Human sperm-egg binding is inhibited by peptides corresponding to core region of an acrosomal serine protease inhibitor.". Mol. Reprod. Dev. 34 (3): 280–91. doi:10.1002/mrd.1080340308. PMID 8471250.
- Hayashi S, Wakizaka A (1996). "Urinary protein C inhibitor binding region in the A alpha-chain of human fibrinogen.". Blood Coagul. Fibrinolysis 6 (5): 382–7. doi:10.1097/00001721-199507000-00003. PMID 8589203.
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1lq8: Crystal structure of cleaved protein C inhibitor
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2hi9: Crystal Structure of human native protein C inhibitor
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2ol2: High Resolution Structure of Native PCI in Space Group P21
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References
- ^ Christensson, A; Lilja H (Feb. 1994). "Complex formation between protein C inhibitor and prostate-specific antigen in vitro and in human semen". Eur. J. Biochem. (GERMANY) 220 (1): 45–53. ISSN 0014-2956. PMID 7509746.
- ^ Kise, H; Nishioka J, Kawamura J, Suzuki K (May. 1996). "Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor". Eur. J. Biochem. (GERMANY) 238 (1): 88–96. ISSN 0014-2956. PMID 8665956.
- ^ a b España, F; Berrettini M, Griffin J H (Aug. 1989). "Purification and characterization of plasma protein C inhibitor". Thromb. Res. (UNITED STATES) 55 (3): 369–84. ISSN 0049-3848. PMID 2551064.
- ^ Strandberg, K; Kjellberg M, Erb E M, Persson U, Mosher D F, Villoutreix B O, Stenflo J (Dec. 2000). "Activated protein C-protein C inhibitor complex formation: characterization of a neoepitope provides evidence for extensive insertion of the reactive center loop". Biochemistry (UNITED STATES) 39 (51): 15713–20. ISSN 0006-2960. PMID 11123896.
- ^ Geiger, M; Huber K, Wojta J, Stingl L, Espana F, Griffin J H, Binder B R (Aug. 1989). "Complex formation between urokinase and plasma protein C inhibitor in vitro and in vivo". Blood (UNITED STATES) 74 (2): 722–8. ISSN 0006-4971. PMID 2752144.
External links
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