Protein C inhibitor

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Protein C inhibitor

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Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5

PDB rendering based on 1lq8.

Available structures

PDB

Ortholog search: PDBe, RCSB

List of PDB id codes
1LQ8, 1LQ8, 2HI9, 2OL2, 3DY0, 3DY0

Identifiers

Symbols

SERPINA5; PAI-3; PAI3; PCI; PLANH3; PROCI

External IDs

OMIM: 601841 MGI: 107817 HomoloGene: 20159 GeneCards: SERPINA5 Gene

Gene Ontology
Molecular function	• retinoic acid binding • protease binding • serine-type endopeptidase inhibitor activity • glycosaminoglycan binding • heparin binding • peptidase inhibitor activity • phosphatidylcholine binding • acrosin binding
Cellular component	• acrosomal membrane • extracellular region • extracellular region • extracellular region • extracellular space • external side of plasma membrane • membrane • platelet alpha granule • platelet dense tubular network • protein C inhibitor-TMPRSS7 complex • protein C inhibitor-TMPRSS11E complex • protein C inhibitor-PLAT complex • protein C inhibitor-PLAU complex • protein C inhibitor-thrombin complex • protein C inhibitor-KLK3 complex • protein C inhibitor-plasma kallikrein complex • protein complex • protein C inhibitor-coagulation factor V complex • protein C inhibitor-coagulation factor Xa complex • protein C inhibitor-coagulation factor XI complex
Biological process	• transport • lipid transport • spermatogenesis • fusion of sperm to egg plasma membrane • negative regulation of endopeptidase activity • regulation of proteolysis
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
95.03 – 95.06 Mb

Chr 12:
105.34 – 105.34 Mb

PubMed search

[1]

[2]

Protein C inhibitor (PCI, SERPINA5) is a serine protease inhibitor (serpin) which limits the expression of protein C (an anticoagulant).

An N-terminal fragment of PCI is a possible serum biomarker for prostate cancer.^[1]

Contents

1 Interactions
2 See also
3 Further reading
4 References
5 External links

Interactions

Protein C inhibitor has been shown to interact with Prostate specific antigen,^[2]^[3] Protein C^[4]^[5] and PLAU.^[4]^[6]

Suzuki K, Hayashi T (2000). "cis-elements required for expression of human protein C inhibitor gene in HepG2 cells and its androgen-dependent expression in rat reproductive organs.". Semin. Thromb. Hemost. 26 (1): 75–83. doi:10.1055/s-2000-9807. PMID 10805286.
Yasuda T, Nadano D, Iida R, et al. (1992). "Discovery of a genetic polymorphism of human plasma protein C inhibitor (PCI): genetic survey utilizing isoelectric focusing followed by immunoblotting, immunological and biochemical characterization.". Hum. Genet. 89 (3): 265–9. doi:10.1007/BF00220537. PMID 1318261.
Laurell M, Christensson A, Abrahamsson PA, et al. (1992). "Protein C inhibitor in human body fluids. Seminal plasma is rich in inhibitor antigen deriving from cells throughout the male reproductive system.". J. Clin. Invest. 89 (4): 1094–101. doi:10.1172/JCI115689. PMC 442965. PMID 1372913. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442965.
Meijers JC, Chung DW (1991). "Organization of the gene coding for human protein C inhibitor (plasminogen activator inhibitor-3). Assignment of the gene to chromosome 14.". J. Biol. Chem. 266 (23): 15028–34. PMID 1714450.
Kuhn LA, Griffin JH, Fisher CL, et al. (1990). "Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor.". Proc. Natl. Acad. Sci. U.S.A. 87 (21): 8506–10. doi:10.1073/pnas.87.21.8506. PMC 54985. PMID 2172989. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=54985.
Meijers JC, Chung DW (1990). "Evidence for a glycine residue at position 316 in human protein C inhibitor.". Thromb. Res. 59 (2): 389–93. doi:10.1016/0049-3848(90)90142-Y. PMID 2173165.
España F, Berrettini M, Griffin JH (1989). "Purification and characterization of plasma protein C inhibitor.". Thromb. Res. 55 (3): 369–84. doi:10.1016/0049-3848(89)90069-8. PMID 2551064.
Laurell M, Stenflo J (1990). "Protein C inhibitor from human plasma: characterization of native and cleaved inhibitor and demonstration of inhibitor complexes with plasma kallikrein.". Thromb. Haemost. 62 (3): 885–91. PMID 2556811.
Geiger M, Huber K, Wojta J, et al. (1989). "Complex formation between urokinase and plasma protein C inhibitor in vitro and in vivo.". Blood 74 (2): 722–8. PMID 2752144.
Suzuki K, Deyashiki Y, Nishioka J, et al. (1987). "Characterization of a cDNA for human protein C inhibitor. A new member of the plasma serine protease inhibitor superfamily.". J. Biol. Chem. 262 (2): 611–6. PMID 3027058.
Suzuki K, Nishioka J, Hashimoto S (1983). "Protein C inhibitor. Purification from human plasma and characterization.". J. Biol. Chem. 258 (1): 163–8. PMID 6294098.
Christensson A, Lilja H (1994). "Complex formation between protein C inhibitor and prostate-specific antigen in vitro and in human semen.". Eur. J. Biochem. 220 (1): 45–53. doi:10.1111/j.1432-1033.1994.tb18597.x. PMID 7509746.
Zheng X, Geiger M, Ecke S, et al. (1994). "Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa.". Am. J. Physiol. 267 (2 Pt 1): C466–72. PMID 7521127.
Radtke KP, Fernández JA, Greengard JS, et al. (1994). "Protein C inhibitor is expressed in tubular cells of human kidney.". J. Clin. Invest. 94 (5): 2117–24. doi:10.1172/JCI117566. PMC 294656. PMID 7525654. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=294656.
Hayashi S (1994). "Urinary protein C inhibitor binding region in the B beta-chain of human fibrinogen.". Blood Coagul. Fibrinolysis 4 (6): 921–6. doi:10.1097/00001721-199304060-00009. PMID 8148485.
Hayashi T, Suzuki K (1994). "Gene organization of human protein C inhibitor, a member of SERPIN family proteins encoded in five exons.". Int. J. Hematol. 58 (3): 213–24. PMID 8148499.
Billingsley GD, Walter MA, Hammond GL, Cox DW (1993). "Physical mapping of four serpin genes: alpha 1-antitrypsin, alpha 1-antichymotrypsin, corticosteroid-binding globulin, and protein C inhibitor, within a 280-kb region on chromosome I4q32.1.". Am. J. Hum. Genet. 52 (2): 343–53. PMC 1682208. PMID 8381582. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1682208.
Hayashi S, Yamada K (1993). "Binding of urinary protein C inhibitor to fibrin(ogen) and its binding mechanism.". Blood Coagul. Fibrinolysis 4 (1): 153–8. doi:10.1097/00001721-199304010-00027. PMID 8384496.
Moore A, Penfold LM, Johnson JL, et al. (1993). "Human sperm-egg binding is inhibited by peptides corresponding to core region of an acrosomal serine protease inhibitor.". Mol. Reprod. Dev. 34 (3): 280–91. doi:10.1002/mrd.1080340308. PMID 8471250.
Hayashi S, Wakizaka A (1996). "Urinary protein C inhibitor binding region in the A alpha-chain of human fibrinogen.". Blood Coagul. Fibrinolysis 6 (5): 382–7. doi:10.1097/00001721-199507000-00003. PMID 8589203.

PDB gallery

1lq8: Crystal structure of cleaved protein C inhibitor

2hi9: Crystal Structure of human native protein C inhibitor

2ol2: High Resolution Structure of Native PCI in Space Group P21

References

^ "Predicting Prostate Cancer Biochemical Recurrence Using a Panel of Serum Proteomic Biomarkers". http://www.jurology.com/article/S0022-5347%2808%2902986-8/abstract.
^ Christensson, A; Lilja H (February 1994). "Complex formation between protein C inhibitor and prostate-specific antigen in vitro and in human semen". Eur. J. Biochem. (GERMANY) 220 (1): 45–53. doi:10.1111/j.1432-1033.1994.tb18597.x. ISSN 0014-2956. PMID 7509746.
^ Kise, H; Nishioka J, Kawamura J, Suzuki K (May. 1996). "Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor". Eur. J. Biochem. (GERMANY) 238 (1): 88–96. doi:10.1111/j.1432-1033.1996.0088q.x. ISSN 0014-2956. PMID 8665956.
^ ^a ^b España, F; Berrettini M, Griffin J H (August 1989). "Purification and characterization of plasma protein C inhibitor". Thromb. Res. (UNITED STATES) 55 (3): 369–84. doi:10.1016/0049-3848(89)90069-8. ISSN 0049-3848. PMID 2551064.
^ Strandberg, K; Kjellberg M, Erb E M, Persson U, Mosher D F, Villoutreix B O, Stenflo J (December 2000). "Activated protein C-protein C inhibitor complex formation: characterization of a neoepitope provides evidence for extensive insertion of the reactive center loop". Biochemistry (UNITED STATES) 39 (51): 15713–20. doi:10.1021/bi001640h. ISSN 0006-2960. PMID 11123896.
^ Geiger, M; Huber K, Wojta J, Stingl L, Espana F, Griffin J H, Binder B R (August 1989). "Complex formation between urokinase and plasma protein C inhibitor in vitro and in vivo". Blood (UNITED STATES) 74 (2): 722–8. ISSN 0006-4971. PMID 2752144.

External links

The MEROPS online database for peptidases and their inhibitors: I04.004
MeSH Protein+C+inhibitor

v t e Serpins

inhibitory	Alpha 1-antichymotrypsin · Alpha 1-antitrypsin · Alpha 2-antiplasmin · Antithrombin · C1-inhibitor · Heparin cofactor II · Protein C inhibitor · Plasminogen activator inhibitor-1 · Plasminogen activator inhibitor-2 · Protein Z-related protease inhibitor SERPINA1 · SERPINA2 · SERPINA3 · SERPINA4 · SERPINA5 · SERPINA6 · SERPINA7 · SERPINA8 · SERPINA9 · SERPINA14 SERPINB1 · SERPINB2 · SERPINB3 · SERPINB4 · SERPINB5 · SERPINB6 · SERPINB7 · SERPINB8 · SERPINB9 · SERPINB13 SERPINC1 · SERPIND1 · SERPINE1 · SERPINE2 · SERPINE2 · SERPINF1 · SERPING1 · SERPINH1 · SERPINI1 · SERPINI2

Cross class inhibitory	MENT · SCCA-1 · crmA

noninhibitory	Heat shock protein 47 · Maspin · Ovalbumin · SERPINF1 · Thyroxine-binding globulin · Transcortin · SERPINF1

see also disorders of globin and globulin proteins

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