PRPF3
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| PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) | |||||||||||||
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 PDB rendering based on 1x4q. |
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| Identifiers | |||||||||||||
| Symbols | PRPF3; HPRP3; HPRP3P; PRP3; Prp3p; RP18 | ||||||||||||
| External IDs | OMIM: 607301 MGI: 1918017 HomoloGene: 3447 GeneCards: PRPF3 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9129 | 70767 | |||||||||||
| Ensembl | ENSG00000117360 | ENSMUSG00000015748 | |||||||||||
| UniProt | O43395 | Q3UT19 | |||||||||||
| RefSeq (mRNA) | NM_004698 | NM_027541.4 | |||||||||||
| RefSeq (protein) | NP_004689 | NP_081817.2 | |||||||||||
| Location (UCSC) | Chr 1: 150.29 – 150.33 Mb |
Chr 3: 95.63 – 95.66 Mb |
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| PubMed search | [1] | [2] | |||||||||||
U4/U6 small nuclear ribonucleoprotein Prp3 is a protein that in humans is encoded by the PRPF3 gene.[1]
The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF3 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM][1]
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Contents
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Interactions
PRPF3 has been shown to interact with DVL3.[2]
References
- ^ a b "Entrez Gene: PRPF3 PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9129.
- ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
External links
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Xu SY, Schwartz M, Rosenberg T, Gal A (1997). "A ninth locus (RP18) for autosomal dominant retinitis pigmentosa maps in the pericentromeric region of chromosome 1". Hum. Mol. Genet. 5 (8): 1193–7. doi:10.1093/hmg/5.8.1193. PMID 8842740.
- Wang A, Forman-Kay J, Luo Y, et al. (1997). "Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome". Hum. Mol. Genet. 6 (12): 2117–26. doi:10.1093/hmg/6.12.2117. PMID 9328476.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Horowitz DS, Kobayashi R, Krainer AR (1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs". RNA 3 (12): 1374–87. PMC 1369579. PMID 9404889. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1369579.
- Heng HH, Wang A, Hu J (1998). "Mapping of the human HPRP3 and HPRP4 genes encoding U4/U6-associated splicing factors to chromosomes 1q21.1 and 9q31-q33". Genomics 48 (2): 273–5. doi:10.1006/geno.1997.5181. PMID 9521884.
- Xu SY, Rosenberg T, Gal A (1998). "Refined genetic mapping of autosomal dominant retinitis pigmentosa locus RP18 reduces the critical region to 2 cM between D1S442 and D1S2858 on chromosome 1q". Hum. Genet. 102 (4): 493–4. doi:10.1007/s004390050728. PMID 9600251.
- Reidt U, Reuter K, Achsel T, et al. (2000). "Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin". J. Biol. Chem. 275 (11): 7439–42. doi:10.1074/jbc.275.11.7439. PMID 10713041.
- Chakarova CF, Hims MM, Bolz H, et al. (2002). "Mutations in HPRP3, a third member of pre-mRNA splicing factor genes, implicated in autosomal dominant retinitis pigmentosa". Hum. Mol. Genet. 11 (1): 87–92. doi:10.1093/hmg/11.1.87. PMID 11773002.
- Horowitz DS, Lee EJ, Mabon SA, Misteli T (2002). "A cyclophilin functions in pre-mRNA splicing". EMBO J. 21 (3): 470–80. doi:10.1093/emboj/21.3.470. PMC 125845. PMID 11823439. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125845.
- Gonzalez-Santos JM, Wang A, Jones J, et al. (2002). "Central region of the human splicing factor Hprp3p interacts with Hprp4p". J. Biol. Chem. 277 (26): 23764–72. doi:10.1074/jbc.M111461200. PMID 11971898.
- Nottrott S, Urlaub H, Lührmann R (2002). "Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins". EMBO J. 21 (20): 5527–38. doi:10.1093/emboj/cdf544. PMC 129076. PMID 12374753. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=129076.
- Ajuh P, Chusainow J, Ryder U, Lamond AI (2003). "A novel function for human factor C1 (HCF-1), a host protein required for herpes simplex virus infection, in pre-mRNA splicing". EMBO J. 21 (23): 6590–602. doi:10.1093/emboj/cdf652. PMC 136956. PMID 12456665. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=136956.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Martínez-Gimeno M, Gamundi MJ, Hernan I, et al. (2003). "Mutations in the pre-mRNA splicing-factor genes PRPF3, PRPF8, and PRPF31 in Spanish families with autosomal dominant retinitis pigmentosa". Invest. Ophthalmol. Vis. Sci. 44 (5): 2171–7. doi:10.1167/iovs.02-0871. PMID 12714658.
- Reidt U, Wahl MC, Fasshauer D, et al. (2003). "Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide". J. Mol. Biol. 331 (1): 45–56. doi:10.1016/S0022-2836(03)00684-3. PMID 12875835.
- Wada Y, Itabashi T, Sato H, Tamai M (2005). "Clinical features of a Japanese family with autosomal dominant retinitis pigmentosa associated with a Thr494Met mutation in the HPRP3 gene". Graefes Arch. Clin. Exp. Ophthalmol. 242 (11): 956–61. doi:10.1007/s00417-004-0923-x. PMID 15085354.
- Stanĕk D, Neugebauer KM (2004). "Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer". J. Cell Biol. 166 (7): 1015–25. doi:10.1083/jcb.200405160. PMC 2172029. PMID 15452143. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172029.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Maita H, Kitaura H, Ariga H, Iguchi-Ariga SM (2005). "Association of PAP-1 and Prp3p, the products of causative genes of dominant retinitis pigmentosa, in the tri-snRNP complex". Exp. Cell Res. 302 (1): 61–8. doi:10.1016/j.yexcr.2004.08.022. PMID 15541726.
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