| Pseudouridine | |
|---|---|
 |
|
| IUPAC name |
5-[(2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-1H-pyrimidine-2,4-dione
|
| Other names | psi-Uridine, 5-Ribosyluracil, beta-D-Pseudouridine, 5-(beta-D-Ribofuranosyl)uracil |
| Identifiers | |
| CAS number | 1445-07-4 |
| PubChem | 15047 |
| SMILES |
O[C@H]1[C@@H](O)[C@H]([C@]2=CNC(NC2=O)=O)O[C@@H]1CO
|
| Properties | |
| Molecular formula | C9H12N2O6 |
| Molar mass | 244.20 g/mol |
| Appearance | White granular powder |
| Solubility in water | Highly soluble in water. |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
Pseudouridine (abbreviated by the Greek letter psi- Ψ) is the C-glycoside isomer of the nucleoside uridine, and it is the most prevalent of the over one hundred different modified nucleosides found in RNA.[1] Ψ is found in all species and in many classes of RNA including mRNA.[2][3] Ψ is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation.[4]
Recent studies suggest it may offer protection from radiation.[5]
-
Pseudouridine is biosynthesized from uridine via the action of Ψ synthases.
References
- ^ Hamma T, Ferré-D'Amaré AR (2006). "Pseudouridine synthases". Chem. Biol. 13 (11): 1125–35. doi:. PMID 17113994.
- ^ Charette M, Gray MW (2000). "Pseudouridine in RNA: what, where, how, and why". IUBMB Life 49 (5): 341–51. doi:. PMID 10902565.
- ^ Liang XH, Xu YX, MIchaeli S (2002). "The spliced leader-associated RNA is a trypanosome-specific sn(o) RNA that has the potential to guide pseudouridine formation on the SL RNA". RNA 8 (2): 237–246. doi:. PMID 11911368.
- ^ Ferré-D'Amaré AR (2003). "RNA-modifying enzymes". Curr. Opin. Struct. Biol. 13 (1): 49–55. doi:. PMID 12581659.
- ^ Monobe, Manami; Arimoto-Kobayashi, Sakae; Ando, Koichi (2003). "β-Pseudouridine, a beer component, reduces radiation-induced chromosome aberrations in human lymphocytes". Mutation research. Genetic toxicology and environmental mutagenesis 538 (1-2): 93–99. doi:. http://cat.inist.fr/?aModele=afficheN&cpsidt=14885511.
 |
This biochemistry article is a stub. You can help Wikipedia by expanding it. |
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
