PTI can be an abbreviation for:
- Pacific Torah Institute, a high school in Vancouver that is a branch of Chofetz Chaim Yeshiva
- Palomar Testbed Interferometer, a long-baseline interferometer
- Paradigm Technologies, Inc., an engineering and technical support company based in Bedford, Massachusetts, USA
- Pardon the Interruption, an American television sports show
- Pennsylvania Transportation Institute, a research unit of Penn State University's College of Engineering
- Physical Training Instructor
- Physical Training Instructor (Singapore Armed Forces)
- Piedmont Triad International Airport, a major airport in Greensboro, North Carolina
- Pittsburgh Technical Institute, a two-year technical college located in Oakdale, Pennsylvania
- Play Ten Interactive
- Portugal Telecom International
- Post-Tensioning Institute
- Press Trust of India, India's largest news agency
- Premier Travel Inn, a budget hotel chain in the UK (now Premier Inn)
- Pre-trial intervention program, a diversionary program designed for first-time offenders of non-violent crimes to perform public service and receive counseling in lieu of a formal trial and sentencing
- Phenix Telecom International, a telecom company located in Paris, France
- Pakistan Tehreek-e-Insaf, a political party headed by Pakistani cricketer turned politician Imran Khan
- Ti plasmid (pTi), used in creation of transgenic plants.
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