PTPRJ

Protein tyrosine phosphatase, receptor type, J
PDB rendering based on 2cfv.
Available structures PDB 2CFV, 2DLE, 2NZ6
Identifiers
Symbols	PTPRJ; CD148; DEP1; HPTPeta; R-PTP-ETA; SCC1
External IDs	OMIM: 600925 MGI: 104574 HomoloGene: 2130 GeneCards: PTPRJ Gene
EC number	3.1.3.48
Gene Ontology Molecular function • protein tyrosine phosphatase activity • protein tyrosine phosphatase activity • platelet-derived growth factor receptor binding • protein binding • beta-catenin binding • hydrolase activity • phosphatase activity • phosphatase activity • protein kinase binding • gamma-catenin binding • mitogen-activated protein kinase binding • delta-catenin binding Cellular component • immunological synapse • plasma membrane • integral to plasma membrane • cell-cell junction • cell surface • ruffle membrane • cell projection Biological process • vasculogenesis • heart development • negative regulation of cell proliferation • negative regulation of platelet-derived growth factor receptor signaling pathway • regulation of cell adhesion • negative regulation of cell growth • negative regulation of cell migration • peptidyl-tyrosine dephosphorylation • peptidyl-tyrosine dephosphorylation • negative regulation of epidermal growth factor receptor signaling pathway • negative regulation of vascular permeability • negative regulation of MAP kinase activity • positive regulation of cell adhesion • positive regulation of survival gene product expression • platelet-derived growth factor receptor signaling pathway • negative regulation of T cell receptor signaling pathway • negative regulation of T cell receptor signaling pathway • positive chemotaxis • positive regulation of focal adhesion assembly • positive regulation of protein kinase B signaling cascade • negative regulation of protein kinase B signaling cascade • contact inhibition • negative regulation of receptor activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5795	19271
Ensembl	ENSG00000149177	ENSMUSG00000025314
UniProt	Q12913	n/a
RefSeq (mRNA)	NM_001098503.1	NM_008982
RefSeq (protein)	NP_001091973.1	NP_033008
Location (UCSC)	Chr 11: 48 – 48.19 Mb	Chr 2: 90.27 – 90.42 Mb
PubMed search	[1]	[2]

Receptor-type tyrosine-protein phosphatase eta is an enzyme that in humans is encoded by the PTPRJ gene.^[1][2][3]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This PTP is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and Linker for Activation of T Cells (LAT). This PTP was also found to dephosphorylate PDGF beta receptor, and may be involved in UV-induced signal transduction.^[3]

Interactions

PTPRJ has been shown to interact with CTNND1.^[4]

References

Further reading

v · d · ePDB gallery 2cfv: CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE J   2dle: Solution structure of the fourth fn3 domain of human receptor-type tyrosine-protein phosphatase eta   2nz6: Crystal structure of the PTPRJ inactivating mutant C1239S

This article on a gene on chromosome 11 is a stub. You can help Wikipedia by expanding it.v · d · e