PTPRN2
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PTPRN2
| Protein tyrosine phosphatase, receptor type, N polypeptide 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | PTPRN2; IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2 | ||||||||||||
| External IDs | OMIM: 601698 MGI: 107418 HomoloGene: 2134 GeneCards: PTPRN2 Gene | ||||||||||||
| EC number | 3.1.3.48 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5799 | 19276 | |||||||||||
| Ensembl | ENSG00000155093 | ENSMUSG00000056553 | |||||||||||
| UniProt | Q92932 | Q1RLJ1 | |||||||||||
| RefSeq (mRNA) | NM_002847.3 | NM_011215.2 | |||||||||||
| RefSeq (protein) | NP_002838.2 | NP_035345.2 | |||||||||||
| Location (UCSC) | Chr 7: 157.33 – 158.38 Mb |
Chr 12: 117.72 – 118.52 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Receptor-type tyrosine-protein phosphatase N2 is an enzyme that in humans is encoded by the PTPRN2 gene.[1][2][3]
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.[3]
References
- ^ Smith PD, Barker KT, Wang J, Lu YJ, Shipley J, Crompton MR (Jan 1997). "ICAAR, a novel member of a new family of transmembrane, tyrosine phosphatase-like proteins". Biochem Biophys Res Commun 229 (2): 402–11. doi:10.1006/bbrc.1996.1817. PMID 8954911.
- ^ Li Q, Borovitskaya AE, DeSilva MG, Wasserfall C, Maclaren NK, Notkins AL, Lan MS (Sep 1997). "Autoantigens in insulin-dependent diabetes mellitus: molecular cloning and characterization of human IA-2 beta". Proc Assoc Am Physicians 109 (4): 429–39. PMID 9220540.
- ^ a b "Entrez Gene: PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5799.
Further reading
- Lan MS, Lu J, Goto Y, Notkins AL (1994). "Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma.". DNA Cell Biol. 13 (5): 505–14. doi:10.1089/dna.1994.13.505. PMID 8024693.
- Cui L, Yu WP, DeAizpurua HJ, et al. (1996). "Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes.". J. Biol. Chem. 271 (40): 24817–23. doi:10.1074/jbc.271.40.24817. PMID 8798755.
- Kawasaki E, Hutton JC, Eisenbarth GS (1996). "Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes.". Biochem. Biophys. Res. Commun. 227 (2): 440–7. doi:10.1006/bbrc.1996.1526. PMID 8878534.
- Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
- Schmidli RS, Colman PG, Cui L, et al. (1998). "Antibodies to the protein tyrosine phosphatases IAR and IA-2 are associated with progression to insulin-dependent diabetes (IDDM) in first-degree relatives at-risk for IDDM.". Autoimmunity 28 (1): 15–23. doi:10.3109/08916939808993841. PMID 9754810.
- van den Maagdenberg AM, Schepens JT, Schepens MT, et al. (1999). "Assignment of Ptprn2, the gene encoding receptor-type protein tyrosine phosphatase IA-2beta, a major autoantigen in insulin-dependent diabetes mellitus, to mouse chromosome region 12F.". Cytogenet. Cell Genet. 82 (3-4): 153–5. doi:10.1159/000015090. PMID 9858807.
- Berghs S, Aggujaro D, Dirkx R, et al. (2001). "betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system.". J. Cell Biol. 151 (5): 985–1002. doi:10.1083/jcb.151.5.985. PMC 2174349. PMID 11086001. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2174349.
- Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187542.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Kubosaki A, Gross S, Miura J, et al. (2004). "Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice.". Diabetes 53 (7): 1684–91. doi:10.2337/diabetes.53.7.1684. PMID 15220191.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
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