Quinazoline

Quinazoline
IUPAC name Quinazoline
Other names Benzopyrimidine
Identifiers
CAS number	253-82-7 Y
PubChem	9210
ChemSpider	8855 Y
ChEBI	CHEBI:36621 Y
ChEMBL	CHEMBL301359 Y
Jmol-3D images	Image 1
SMILES c1ccc2c(c1)cncn2
InChI InChI=1S/C8H6N2/c1-2-4-8-7(3-1)5-9-6-10-8/h1-6H Y Key: JWVCLYRUEFBMGU-UHFFFAOYSA-N Y InChI=1/C8H6N2/c1-2-4-8-7(3-1)5-9-6-10-8/h1-6H Key: JWVCLYRUEFBMGU-UHFFFAOYAV
Properties
Molecular formula	C8H6N2
Molar mass	130.15 g/mol
Acidity (pKa)	3.31[1]
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Quinazoline is a compound made up of two fused six-membered simple aromatic rings, a benzene ring and a pyrimidine ring. Its chemical formula is C₈H₆N₂. Quinazoline is yellow and crystalline. Any derivative of quinazoline may be described as a quinazoline compound.

Medicinally it has been used in various areas especially as an anti-malarial agent and in cancer treatment. One example of a compound containing the quinazoline structure is doxazosin mesylate.

It is isomeric with quinoxaline, phthalazine and cinnoline.

See also

• Quinoxaline
• Quinazolinone
• Niementowski quinazoline synthesis

References

1. ^ Brown, H.C., et al., in Baude, E.A. and Nachod, F.C., Determination of Organic Structures by Physical Methods, Academic Press, New York, 1955.