Quinazolinone
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Quinazolinone
| 4-Quinazolinone | |
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Quinazolin-4(3H)-one |
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Other names
4(3H)-Quinazolinone; 4(1H)-Quinazolinone; 3,4-Dihydroquinazolin-4-one; 4(3H)-Quinazolone; 4-Hydroxyquinazoline; 4-Oxo-3,4-dihydroquinazoline; 4-Oxoquinazoline; 4-Quinazolinol; 4-Quinazolinone; 4-Quinazolone |
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| Identifiers | |
| CAS number | 491-36-1 |
| PubChem | 63112 |
| ChemSpider | 56797 |
| ChEMBL | CHEMBL266540 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C8H6N2O |
| Molar mass | 146.15 g mol−1 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
Quinazolinone is a heterocyclic chemical compound. There are two structural isomers, 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common.
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2-Quinazolinone
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4-Quinazolinone
Derivatives
Quinazolinones are also a class of drugs which function as hypnotic/sedatives that contain a 4-quiazolinone core. Their use has also been proposed in the treatment of cancer.[1] Examples include afloqualone, cloroqualone, and diproqualone.
Alkaloids containing the quinzolinone core include febrifugine and halofuginone.
References
- ^ Chen K, Wang K, Kirichian AM, et al. (December 2006). "In silico design, synthesis, and biological evaluation of radioiodinated quinazolinone derivatives for alkaline phosphatase-mediated cancer diagnosis and therapy". Mol. Cancer Ther. 5 (12): 3001–13. doi:10.1158/1535-7163.MCT-06-0465. PMID 17172404. http://mct.aacrjournals.org/cgi/pmidlookup?view=long&pmid=17172404.
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