Quinpirole
Wikipedia on Answers.com:
Top
Quinpirole
| Quinpirole | |
|---|---|
 |
|
|
(4aR,8aR)-5-propyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]quinoline |
|
| Identifiers | |
| CAS number | 80373-22-4  |
| PubChem | 54562 |
| ChEMBL | CHEMBL240773  |
| IUPHAR ligand | 2 |
| Properties | |
| Molecular formula | C13H21N3 |
| Molar mass | 219.33 g mol−1 |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
|
| Infobox references | |
Quinpirole is a psychoactive drug and research chemical which acts as a selective D2 and D3 receptor agonist. It is used in scientific research.[1][2][3] Quinpirole has been shown to increase locomotion and sniffing behavior in mice treated with it. At least one study has found that quinpirole induces compulsive behavior symptomatic of obsessive compulsive disorder in rats.[4]
See also
References
- ^ Eilam D, Szechtman H (February 1989). "Biphasic effect of D-2 agonist quinpirole on locomotion and movements". European Journal of Pharmacology 161 (2–3): 151–7. doi:10.1016/0014-2999(89)90837-6. PMID 2566488.
- ^ Navarro JF, Maldonado E (September 1999). "Behavioral profile of quinpirole in agonistic encounters between male mice". Methods and Findings in Experimental and Clinical Pharmacology 21 (7): 477–80. PMID 10544391.
- ^ Culm KE, Lugo-Escobar N, Hope BT, Hammer RP (October 2004). "Repeated quinpirole treatment increases cAMP-dependent protein kinase activity and CREB phosphorylation in nucleus accumbens and reverses quinpirole-induced sensorimotor gating deficits in rats". Neuropsychopharmacology 29 (10): 1823–30. doi:10.1038/sj.npp.1300483. PMID 15138441.
- ^ Szechtman, Henry; Sulis, William; Eilam, David (1998). "Quinpirole induces compulsive checking behavior in rats: A potential animal model of obsessive-compulsive disorder (OCD)". Behavioral Neuroscience 112 (6): 1475–85. doi:10.1037/0735-7044.112.6.1475. PMID 9926830.
 |
This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it. |
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
Post a question - any question - to the WikiAnswers community:
Copyrights:
Wikipedia on Answers.com
This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article Quinpirole.
Read more