R16, R-XVI or R-16 may refer to :
- R-16 (missile), the first successful intercontinental ballistic missile deployed by the Soviet Union
- R16 (New York City Subway car)
- R16: Explosive when mixed with oxidising substances, a risk phrase in chemistry
- AIKa R-16: Virgin Mission, an anime OVA series by Studio Fantasia
- Lublin R-XVI, a 1932 Polish passenger and air ambulance aircraft
- USS R-16 (SS-93), a 1917 R-class coastal and harbor defense submarine of the United States Navy
and also :
- Renault 16, a 1965 large family car
- Hepatomegaly and splenomegaly, not elsewhere classified ICD-10 code
- R16 Korea, international b-boy competition
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