Rasburicase
Drug Info:
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Rasburicase
Brand names: Elitek®
- Drug Forms:
- Rasburicase Injection (below)
- Rasburicase Solution for injection
Rasburicase Injection
What is Rasburicase injection?
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:• G6PD deficiency
• history of anemia
• history of blood transfusion
• an unusual reaction to rasburicase, yeast, mannitol, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding
How should this medicine be used?
Rasburicase is for infusion into a vein. A health-care professional will give this drug to you in a hospital or clinic setting.Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed. This drug is regularly used in children.
What if I miss a dose?
What drug(s) may interact with Rasburicase?
• allopurinolTell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
What should I watch for while taking Rasburicase?
What side effects may I notice from receiving Rasburicase?
Side effects that you should report to your prescriber or health care professional as soon as possible:• chest pain
• dizziness
• fever
• itching
• rapid heart beat
• skin rash or hives
• trouble breathing
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• constipation
• diarrhea
• headache
• nausea
• stomach pain
Where can I keep my medicine?
Rasburicase injection will be given to you in a clinic or hospital setting. You will not take this medicine at home.Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
Oxford A-Z of Medicinal Drugs:
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rasburicase
A genetically engineered form of an enzyme that breaks down uric acid. It is used to lower uric acid levels in the blood in patients with leukaemia or lymphoma who are receiving chemotherapy. Rasburicase is available as a form for intravenous infusion on prescription only.
Side effects:
include fever.
Precautions:
rasburicase should not be given to pregnant or breastfeeding women or to people with metabolic disorders that cause the breakdown of red blood cells. There is a risk of allergic reactions and patients should be monitored for signs of these.
Proprietary preparation:
Fasturtec.
| rasagiline, ranolazine, ranitidine | |
| reboxetine, remifentanil, repaglinide |
Wikipedia on Answers.com:
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Rasburicase
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|---|---|
| Systematic (IUPAC) name | |
| Aspergillus urate oxidase | |
| Clinical data | |
| AHFS/Drugs.com | monograph |
| Pregnancy cat. | ? |
| Legal status | RX/POM |
| Routes | Intravenous |
| Pharmacokinetic data | |
| Bioavailability | N/A |
| Half-life | 18 hrs |
| Identifiers | |
| CAS number | 134774-45-1  |
| ATC code | V03AF07 |
| DrugBank | DB00049 |
| UNII | 08GY9K1EUO |
| ChEMBL | CHEMBL1201594  |
| Chemical data | |
| Formula | C1521H2381N417O461S7 |
| Mol. mass | 34109.5 |
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Rasburicase (brand names: Elitek in the US, and Fasturtec in Europe ) is a recombinant version of urate oxidase, an enzyme which occurs in many mammals but not in humans.
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Contents
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Uses
Rasburicase is approved for use by the U.S. Food and Drug Administration (FDA) (and European counterparts) for the prevention and treatment of tumor lysis syndrome (TLS)[1] in patients receiving chemotherapy for hematologic cancers such as leukemias and lymphomas. It is also being investigated for treating severe hyperuricemia from other sources (e.g., gout[2] and other rheumatologic conditions).
It catalyses the conversion of uric acid to allantoin. Allantoin is an inactive metabolite of purine metabolism, and is five to ten times more soluble than uric acid, so renal excretion is more effective. Rasburicase is unique as a treatment and prevention for renal failure associated with TLS in that it catalyses the metabolism of existing uric acid. Other options prevent uric acid formation.
Rasburicase reduces the risk of renal failure and the need for transfusion. Transfusion has been reported as required in 17 to 25% of TLS cases treated with allopurinol, and 1.4% of cases treated with rasburicase.[citation needed]
However, rasburicase is much more expensive than conventional therapy.[3]
Side effects
Side effects of rasburicase administration can include anaphylaxis (incidence unknown) and methemoglobinemia.
See also
- Allopurinol is also indicated for TLS to reduce the blood concentration of uric acid.[citation needed]
- Pegloticase is a pegylated variant of the uricase enzyme which has been approved for the treatment of refractory gout.
References
- ^ Ho VQ, Wetzstein GA, Patterson SG, Bradbury R (April 2006). "Abbreviated rasburicase dosing for the prevention and treatment of hyperuricemia in adults at risk for tumor lysis syndrome". Supportive cancer therapy 3 (3): 178–82. doi:10.3816/SCT.2006.n.016. PMID 18632493. http://cigjournals.metapress.com/openurl.asp?genre=article&id=doi:10.3816/SCT.2006.n.016.
- ^ Cammalleri L, Malaguarnera M (2007). "Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout". International journal of medical sciences 4 (2): 83–93. PMC 1838823. PMID 17396159. http://www.medsci.org/v04p0083.htm.
- ^ Reinders MK, van Roon EN, Brouwers JR, Jansen TL (March 2005). "A costly therapeutic dilemma in tophaceous gout: is etanercept or rasburicase preferable?". Annals of the rheumatic diseases 64 (3): 516; author reply 516. doi:10.1136/ard.2003.017087corr1. PMC 1755382. PMID 15708917. http://ard.bmj.com/cgi/pmidlookup?view=long&pmid=15708917.
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External links
- Elitek (Rasburicase) - Official web site of manufacturer.
- Elitek (Rasburicase) Prescribing Information - Official Prescribing Information of manufacturer.
- [1] - Elitek (Rasburicase)
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Oxford A-Z of Medicinal Drugs
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