RASGRP3
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RASGRP3
| RAS guanyl releasing protein 3 (calcium and DAG-regulated) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | RASGRP3; GRP3; KIAA0846 | ||||||||||||
| External IDs | OMIM: 609531 MGI: 3028579 HomoloGene: 15019 GeneCards: RASGRP3 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 25780 | 240168 | |||||||||||
| Ensembl | ENSG00000152689 | ENSMUSG00000071042 | |||||||||||
| UniProt | Q8IV61 | n/a | |||||||||||
| RefSeq (mRNA) | NM_001139488.1 | NM_207246 | |||||||||||
| RefSeq (protein) | NP_001132960.1 | NP_997129 | |||||||||||
| Location (UCSC) | Chr 2: 33.66 – 33.79 Mb |
Chr 17: 75.84 – 75.93 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Ras guanyl-releasing protein 3 is a protein that in humans is encoded by the RASGRP3 gene.[1][2][3]
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[supplied by OMIM][3]
Interactions
RASGRP3 has been shown to interact with PRKCD.[4]
References
- ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
- ^ Rebhun JF, Castro AF, Quilliam LA (Nov 2000). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction". J Biol Chem 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204.
- ^ a b "Entrez Gene: RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25780.
- ^ Brodie, Chaya; Steinhart Rivka, Kazimirsky Gila, Rubinfeld Hadara, Hyman Tehila, Ayres Jolene N, Hur Gang Min, Toth Attila, Yang Dazhi, Garfield Susan H, Stone James C, Blumberg Peter M (Jul. 2004). "PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters". Mol. Pharmacol. (United States) 66 (1): 76–84. doi:10.1124/mol.66.1.76. ISSN 0026-895X. PMID 15213298.
Further reading
- Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948.
- Lorenzo PS, Kung JW, Bottorff DA, et al. (2001). "Phorbol esters modulate the Ras exchange factor RasGRP3". Cancer Res. 61 (3): 943–9. PMID 11221888.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Teixeira C, Stang SL, Zheng Y, et al. (2003). "Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3". Blood 102 (4): 1414–20. doi:10.1182/blood-2002-11-3621. PMID 12730099.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Brodie C, Steinhart R, Kazimirsky G, et al. (2004). "PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters". Mol. Pharmacol. 66 (1): 76–84. doi:10.1124/mol.66.1.76. PMID 15213298.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930.
- Aiba Y, Oh-hora M, Kiyonaka S, et al. (2004). "Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation". Proc. Natl. Acad. Sci. U.S.A. 101 (47): 16612–7. doi:10.1073/pnas.0407468101. PMC 528733. PMID 15545601. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528733.
- Roberts DM, Anderson AL, Hidaka M, et al. (2004). "A Vascular Gene Trap Screen Defines RasGRP3 as an Angiogenesis-Regulated Gene Required for the Endothelial Response to Phorbol Esters". Mol. Cell. Biol. 24 (24): 10515–28. doi:10.1128/MCB.24.24.10515-10528.2004. PMC 533983. PMID 15572660. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=533983.
- Zheng Y, Liu H, Coughlin J, et al. (2005). "Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells". Blood 105 (9): 3648–54. doi:10.1182/blood-2004-10-3916. PMID 15657177.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501.
- Okamura SM, Oki-Idouchi CE, Lorenzo PS (2007). "The exchange factor and diacylglycerol receptor RasGRP3 interacts with dynein light chain 1 through its C-terminal domain". J. Biol. Chem. 281 (47): 36132–9. doi:10.1074/jbc.M605093200. PMID 17012239.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
- Randhawa PK, Rylova S, Heinz JY, et al. (2011). "The Ras Activator RasGRP3 Mediates Diabetes-Induced Embryonic Defects and Affects Endothelial Cell Migration". Circ Res. 108 (10): 1199–1208. doi:10.1161/CIRCRESAHA.110.230888. PMID 21474816.
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