recA
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a gene in Escherichia coli encoding a protein, RecA, involved in genetic recombination and in the SOS response for DNA repair (see SOS repair). The protein has two activities: (1) a DNA-dependent ATPase in the presence of single-stranded DNA that catalyses the ATP-dependent uptake of single-stranded DNA to form the heteroduplex required in recombination. (2) In the presence of DNA fragments it becomes a protease (RecA* EC 3.4.99.37) that cleaves a specific Ala-|-Gly bond in certain repressor molecules, including its own repressor (see lexA). This allows all the SOS genes to be activated. See also exodeoxyribonuclease V, recombinational repair, recombinase.
| rearrangement reaction, rearrangase, real-time PCR | |
| recBC, recDNA, recalcitrance |
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Oxford Dictionary of Biochemistry
Oxford University Press. Oxford Dictionary of Biochemistry and Molecular Biology © 1997, 2000, 2006 All rights reserved.
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