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Reed-Sternberg cell

 
Dictionary: Reed-Stern·berg cell   (rēd'stûrn'bûrg') pronunciation
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n.
A giant binucleated or multinucleated macrophage that is characteristic of Hodgkin's disease.

[After Dorothy M. Reed (1874-1964), American pathologist, and Carl Sternberg (1872-1935), Austrian pathologist.]


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Medical Dictionary: Reed-Sternberg cell
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n.

A giant binucleated or multinucleated acidophilic cell in the tissues in Hodgkin's disease. Also called Sternberg-Reed cell.

Wikipedia: Reed-Sternberg cell
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Reed-Sternberg lymphocyte nci-vol-7172-300.jpg

Reed-Sternberg cells (also known as lacunar histiocytes for certain types) are different giant cells found on light microscopy in biopsies from individuals with Hodgkin's lymphoma (aka Hodgkin's disease; a type of lymphoma), and certain other disorders. They are usually derived from B lymphocytes.[1]

They are named after Dorothy Reed Mendenhall (1874-1964) and Carl Sternberg (1872-1935), who provided the first definitive microscopic descriptions of Hodgkin's disease.[2][3]

Reed-Sternberg cells are large and are either multinucleated or have a bilobed nucleus (thus resembling an "owl's eye" appearance) with prominent eosinophilic inclusion-like nucleoli. Reed-Sternberg cells are CD30 and CD15 positive, usually negative for CD20 and CD45. The presence of these cells is pathognomonic for the diagnosis of classical Hodgkin's lymphoma. They can also be found in reactive lymphadenopathy (such as infectious mononucleosis, carbamazepine associated lymphadenopathy) and rarely non-Hodgkin lymphomas.

References

  1. ^ Hartlapp I, Pallasch C, Weibert G, Kemkers A, Hummel M, Re D (February 2009). "Depsipeptide induces cell death in Hodgkin lymphoma-derived cell lines". Leuk. Res.. doi:10.1016/j.leukres.2008.12.013. PMID 19233470. 
  2. ^ Reed D. On the pathological changes in Hodgkin's disease, with special reference to its relation to tuberculosis. Johns Hopkins Hosp Rep 1902;10:133-96.
  3. ^ Sternberg C. Uber eine eigenartige unter dem Bilde der Pseudoleukamie verlaufende Tuberculose des lymphatischen Apparates. Ztschr Heilk 1898;19:21-90.

See also


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Dictionary. The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2009. Published by Houghton Mifflin Company. All rights reserved.  Read more
Medical Dictionary. The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Reed-Sternberg cell".  Read more