Reed-Sternberg cell
American Heritage Dictionary:
Top
Reed-Stern·berg cell
(rēd'stûrn'bûrg') 
n.
A giant binucleated or multinucleated macrophage that is characteristic of Hodgkin's disease.
n.
A giant binucleated or multinucleated macrophage that is characteristic of Hodgkin's disease.
[After Dorothy M. Reed (1874-1964), American pathologist, and Carl Sternberg (1872-1935), Austrian pathologist.]
Related Videos:
Top
Reed-Sternberg cell
American Heritage Stedman's Medical Dictionary:
Top
Reed-Sternberg cell
n.
A giant binucleated or multinucleated acidophilic cell in the tissues in Hodgkin's disease. Also called Sternberg-Reed cell.
Wikipedia on Answers.com:
Top
Reed–Sternberg cell
Reed–Sternberg cells (also known as lacunar histiocytes for certain types) are different giant cells found with light microscopy in biopsies from individuals with Hodgkin's lymphoma (aka Hodgkin's disease; a type of lymphoma) primarily due to EBV, and certain other disorders. They are usually derived from B lymphocytes.[1]
They are named after Dorothy Reed Mendenhall (1874–1964) and Carl Sternberg (1872–1935), who provided the first definitive microscopic descriptions of Hodgkin's disease.[2][3]
Reed–Sternberg cells are large and are either multinucleated or have a bilobed nucleus (thus resembling an "owl's eye" appearance) with prominent eosinophilic inclusion-like nucleoli. Reed-Sternberg cells are CD30 and CD15 positive, usually negative for CD20 and CD45. The presence of these cells is necessary in the diagnosis of Hodgkin's lymphoma – the absence of Reed–Sternberg cells has very high negative predictive value. They can also be found in reactive lymphadenopathy (such as infectious mononucleosis, carbamazepine associated lymphadenopathy) and very rarely non-Hodgkin lymphomas.
A special type of Reed–Sternberg cells are lacunar histiocytes, whose cytoplasm retracts when fixed in formalin, so the nuclei give the appearance of cells that lie with empty spaces (called lacunae) between them.[4] These are characteristic of the nodular sclerosis subtype of Hodgkin's lymphoma.[4]
References
- ^ Hartlapp I, Pallasch C, Weibert G, Kemkers A, Hummel M, Re D (February 2009). "Depsipeptide induces cell death in Hodgkin lymphoma-derived cell lines". Leuk. Res. 33 (7): 929–36. doi:10.1016/j.leukres.2008.12.013. PMID 19233470.
- ^ Reed D. On the pathological changes in Hodgkin's disease, with special reference to its relation to tuberculosis. Johns Hopkins Hosp Rep 1902;10:133-96.
- ^ Sternberg C. Uber eine eigenartige unter dem Bilde der Pseudoleukamie verlaufende Tuberculose des lymphatischen Apparates. Ztschr Heilk 1898;19:21–90.
- ^ a b Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7. 8th edition.
See also
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
Post a question - any question - to the WikiAnswers community:
Copyrights:
American Heritage Dictionary
The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2009. Published by Houghton Mifflin Company. All rights reserved.
Read more
American Heritage Stedman's Medical Dictionary
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company.
Read more
