Renal papillary necrosis
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Renal papillary necrosis
| Renal papillary necrosis | |
|---|---|
| Classification and external resources | |
| ICD-10 | N17.2 |
| ICD-9 | 584.7 |
| DiseasesDB | 9572 |
| eMedicine | med/2839 radio/523 |
| MeSH | D007681 |
Renal papillary necrosis is a form of nephropathy involving the necrosis of the renal papilla,[1] which is supplied by the vasa recta.
Causes
Analgesic nephropathy is a cause of renal papillary necrosis.[2] The damage is cumulative and most patients of renal papillary necrosis would have ingested at least 20 kg of analgesics in the past. The risk is higher for phenacetin and acetaminophen (paracetamol) compared to aspirin and other NSAIDs. Combination analgesic products, such as Goody's, also have a high risk of causing papillary necrosis.
It can be an outcome of chronic analgesic nephritis, with persistent use or abuse of phenacetin or its derivatives (such as Acetaminophen). This is less common since phenacetin is no longer available over the counter. But is more common when patient's taken combination analgesic products for an extended period of time.
It is also caused by diabetes mellitus and vaso-occlusive sickle cell crises, in which it is related to renal infection or vascular disease.
It can also occur as a result of acute pyelonephritis[3] or sickle cell disease.[4]
References
- ^ Jung DC, Kim SH, Jung SI, Hwang SI, Kim SH (2006). "Renal papillary necrosis: review and comparison of findings at multi-detector row CT and intravenous urography". Radiographics : a review publication of the Radiological Society of North America, Inc 26 (6): 1827–36. DOI:10.1148/rg.266065039. PMID 17102053. http://radiographics.rsnajnls.org/cgi/pmidlookup?view=long&pmid=17102053.
- ^ "Renal Pathology". http://library.med.utah.edu/WebPath/RENAHTML/RENAL172.html. Retrieved 2008-11-26.
- ^ Powell, Christopher. "Papillary Necrosis". Medscape Reference. http://emedicine.medscape.com/article/439586. Retrieved 10 Nov 2011.
- ^ Zadeii G, Lohr JW (June 1997). "Renal papillary necrosis in a patient with sickle cell trait". J. Am. Soc. Nephrol. 8 (6): 1034–9. PMID 9189873. http://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=9189873.
External links
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