Renin inhibitor: Information from Answers.com

Renin inhibitor, or inhibitors of renin, are a new group of pharmaceuticals that are used primarily in treatment of hypertension.

They act on the juxtaglomerular cells of kidney, which produce renin in response to decreased blood flow.

1 Examples
2 See also
3 References
4 External links

Examples

Aliskiren ^[1]
Remikiren

References

^ Gradman AH, Schmieder RE, Lins RL, Nussberger J, Chiang Y, Bedigian MP (March 2005). "Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients". Circulation 111 (8): 1012–8. doi:10.1161/01.CIR.0000156466.02908.ED. PMID 15723979. http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=15723979.

External links

Renin inhibitor aliskiren leads to dose-dependent blood pressure reductions - medicalnewstoday.com.

v • d • e Pharmacology: Major drug groups

Gastrointestinal tract/metabolism (A)	stomach acid (Antacids, H₂ antagonists, Proton pump inhibitors) • Antiemetics • Laxatives • Antidiarrhoeals/Antipropulsives • Anti-obesity drugs • Anti-diabetics • Vitamins • Dietary minerals

Blood and blood forming organs (B)	Antithrombotics (Antiplatelets, Anticoagulants, Thrombolytics/fibrinolytics) • Antihemorrhagics (Platelets, Coagulants, Antifibrinolytics)

Cardiovascular system (C)	cardiac therapy/antianginals (Cardiac glycosides, Antiarrhythmics, Cardiac stimulants) Antihypertensives • Diuretics • Vasodilators • Beta blockers • Calcium channel blockers • renin-angiotensin system (ACE inhibitors, Angiotensin II receptor antagonists, Renin inhibitors) Antihyperlipidemics (Statins, Fibrates, Bile acid sequestrants)

Skin (D)	Emollients • Cicatrizants • Antipruritics • Antipsoriatics • Medicated dressings

Reproductive system (G)	Hormonal contraception • Fertility agents • SERMs • Sex hormones

Endocrine system (H)	Hypothalamic-pituitary hormones • Corticosteroids (Glucocorticoids, Mineralocorticoids) • Sex hormones • Thyroid hormones/Antithyroid agents

Infections and infestations (J, P, QI)	Antibiotics (Antimycobacterials) • Antifungals • Antivirals • Antiparasitics (Antiprotozoals, Anthelmintics) • Ectoparasiticides • Intravenous immunoglobulin • Vaccines

Malignant disease (L01-L02)	Anticancer agents (Antimetabolites, Alkylating, Spindle poisons, Antineoplastic, Topoisomerase inhibitors)

Immune disease (L03-L04)	Immunomodulators (Immunostimulants, Immunosuppressants)

Muscles, bones, and joints (M)	Anabolic steroids • Anti-inflammatories (NSAIDs) • Antirheumatics • Corticosteroids • Muscle relaxants • Bisphosphonates

Brain and nervous system (N)	Anesthetics (General, Local) • Analgesics • Antimigraines • Anticonvulsants/Mood stabilizers (Lithium pharmacology) • Antiparkinson drugs Psycholeptics (Anxiolytics, Antipsychotics, Hypnotics/Sedatives) • Psychoanaleptics (Antidepressants, Stimulants)

Respiratory system (R)	Decongestants • Bronchodilators • Cough medicines • H₁ antagonists

Sensory organs (S)	Ophthalmologicals • Otologicals

Other ATC (V)	Antidotes • Contrast media • Radiopharmaceuticals • Dressings

v • d • e Antihypertensives: agents acting on the renin-angiotensin system (C09)

ACE inhibitors ("-pril")	Sulfhydryl-containing: Captopril • Zofenopril Dicarboxylate-containing: Enalapril^# • Ramipril • Quinapril • Perindopril • Lisinopril • Benazepril Phosphonate-containing: Fosinopril Other/ungrouped: Alacepril • Cilazapril • Delapril • Imidapril • Moexipril • Rentiapril • Spirapril • Temocapril • Trandolapril

AIIRAs/ ("-sartan")	Azilsartan • Candesartan • Eprosartan • Irbesartan • Losartan • Olmesartan • Tasosartan • Telmisartan • Valsartan

Renin inhibitors/ ("-kiren")	Aliskiren • Remikiren

^#WHO-EM. ^‡Withdrawn from market. CLINICAL TRIALS: ^†Phase III. ^§Never to phase III

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Renin inhibitor

Contents

Examples

See also

References

External links