RhoGTPase

any of a subfamily of Ras-related GTPases that are involved in the assembly of actin microfilaments into stress fibres and in formation of the contractile ring during cell division. They have crucial roles in metazoan development because they regulate cell shape, adhesion, and migration. There are at least ten mammalian RhoGTPases (RhoA to RhoE; Rac1, Rac2, and RacE; Cdc42 and TC10), which share ≈50% homology and become prenylated at the C-terminal CAAX motif. They cycle between (active) RhoGTP and (inactive) RhoGDP forms, the relative proportions being regulated by Rho guanine nucleotide-exchange factors (RhoGEFs).

Previous:	RhoGEF, Rho protein, Rhizobium
Next:	Rhodamine, Rib, Rieske protein