Rilonacept
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Rilonacept
| Systematic (IUPAC) name | |
|---|---|
| n/a | |
| Clinical data | |
| AHFS/Drugs.com | monograph |
| Licence data | US FDA:link |
| Pregnancy cat. | C (US) |
| Legal status | ℞-only (US) |
| Routes | Subcutaneous |
| Identifiers | |
| ATC code | L04AC04 |
| UNII | 8K80YB5GMG  |
| ChEMBL | CHEMBL1201830  |
| Chemical data | |
| Formula | ? |
 (what is this?) (verify) |
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Rilonacept, also known as IL-1 Trap (marketed by Regeneron Pharmaceuticals under the trade name Arcalyst), is an interleukin 1 inhibitor.[1]
Rilonacept is a dimeric fusion protein consisting of the extracellular domain of human interleukin-1 receptor and the FC domain of human IgG1 that binds and neutralizes IL-1.[2]
Rilonacept was given an "Orphan Drug" status by the United States Food and Drug Administration and is used for the treatment of cryopyrin-associated periodic syndromes (CAPS), including familial cold autoinflammatory syndrome, Muckle-Wells syndrome and neonatal onset multisystem inflammatory disease(not approved in the U.S. on this indication).[3]
On May 8th, 2012 an FDA Advisory Panel voted 11-0 against the approval of Rilonacept for the treatment of gout, stating that the benefits did not outweigh the risks associated with the drug.[4]
References
- ^ http://ard.bmj.com/cgi/content/short/ard.2009.108936v1?rss=1 "The IL-1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, nonrandomized, single-blind pilot study " Oct 2009
- ^ "Molecule of the month. Rilonacept". Drug News Perspect. 21 (4): 232. May 2008. PMID 18560622.
- ^ "Arcalyst FDA Approval History - Drugs.com". http://www.drugs.com/history/arcalyst.html. Retrieved 2012-05-08.
- ^ "Medical News: FDA Panel Nixes Gout Drug - in Rheumatology, General Rheumatology from MedPage Today". http://www.medpagetoday.com/Rheumatology/GeneralRheumatology/32579. Retrieved 2012-05-08.
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