RNase MRP

RNase MRP
Predicted secondary structure and sequence conservation of RNase_MRP
Identifiers
Symbol	RNase_MRP
Rfam	RF00030
Other data
RNA type	Gene; ribozyme
Domain(s)	Eukaryota
GO	0006364 0000171 0000172
SO	0000385

RNase MRP is an enzymatically active ribonucleoprotein with two distinct roles in eukaryotes. In mitochondria it plays a direct role in the initiation of mitochondrial DNA replication. In the nucleus it is involved in precursor rRNA processing, where it cleaves the internal transcribed spacer 1 between 18S and 5.8S rRNAs. Despite distinct functions, RNase MRP has been shown to be evolutionarily related to RNase P. Like eukaryotic RNase P, RNase MRP is not catalytically active without associated protein subunits.

References

• [1] Schmitt, ME; Bennett JL, Dairaghi DJ, Clayton DA (1993). "Secondary structure of RNase MRP RNA as predicted by phylogenetic comparison". FASEB J 7 (1): 208–213. PMID 7678563. 
• [2] Li, X; Frank DN, Pace N, Zengel JM, Lindahl L (2002). "Phylogenetic analysis of the structure of RNase MRP RNA in yeasts". RNA 8 (6): 740–751. doi:10.1017/S1355838202022082. PMC 1370293. PMID 12088147. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1370293. 
• [3] Kiss, T; Marshallsay C, Filipowicz W (1992). "7-2/MRP RNAs in plant and mammalian cells: association with higher order structures in the nucleolus". EMBO J 11 (10): 3737–3746. PMC 556834. PMID 1382978. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=556834. 

External links

• Rfam page for RNase MRP
• MeSH RNase+MRP

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