RNASE1
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RNASE1
| Ribonuclease, RNase A family, 1 (pancreatic) | |||||||||||
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 PDB rendering based on 1dza. |
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| Identifiers | |||||||||||
| Symbols | RNASE1; MGC12408; RIB1; RNS1 | ||||||||||
| External IDs | OMIM: 180440 MGI: 97919 HomoloGene: 7919 GeneCards: RNASE1 Gene | ||||||||||
| EC number | 3.1.27.5 | ||||||||||
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| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 6035 | 19752 | |||||||||
| Ensembl | ENSG00000129538 | ENSMUSG00000035896 | |||||||||
| UniProt | P07998 | Q8C6G3 | |||||||||
| RefSeq (mRNA) | NM_002933.4 | NM_011271.2 | |||||||||
| RefSeq (protein) | NP_002924.1 | NP_035401.2 | |||||||||
| Location (UCSC) | Chr 14: 21.27 – 21.27 Mb |
Chr 14: 51.76 – 51.77 Mb |
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| PubMed search | [1] | [2] | |||||||||
Ribonuclease pancreatic is an enzyme that in humans is encoded by the RNASE1 gene.[1][2]
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ss-RNA over ds-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.[2]
References
- ^ Kochetov AV, Lukasheva VV, Filipenko ML, Mertvetsov NP, Rivkin MI (Mar 1996). "[Primary structure of the coding part of the gene for human pancreatic ribonuclease and its chromosomal location]". Bioorg Khim 21 (9): 691–4. PMID 8588814.
- ^ a b "Entrez Gene: RNASE1 ribonuclease, RNase A family, 1 (pancreatic)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6035.
Further reading
- Nogués MV, Vilanova M, Cuchillo CM (1996). "Bovine pancreatic ribonuclease A as a model of an enzyme with multiple substrate binding sites.". Biochim. Biophys. Acta 1253 (1): 16–24. PMID 7492594.
- Schienman JE, Holt RA, Auerbach MR, Stewart CB (2006). "Duplication and divergence of 2 distinct pancreatic ribonuclease genes in leaf-eating African and Asian colobine monkeys.". Mol. Biol. Evol. 23 (8): 1465–79. doi:10.1093/molbev/msl025. PMID 16751256.
- Sakakibara R, Hashida K, Kitahara T, Ishiguro M (1992). "Characterization of a unique nonsecretory ribonuclease from urine of pregnant women.". J. Biochem. 111 (3): 325–30. PMID 1587793.
- Haugg M, Schein CH (1992). "The DNA sequences of the human and hamster secretory ribonucleases determined with the polymerase chain reaction (PCR).". Nucleic Acids Res. 20 (3): 612. doi:10.1093/nar/20.3.612. PMC 310435. PMID 1741299. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310435.
- Sakakibara R, Hashida K, Tominaga N, et al. (1991). "A putative mouse oocyte maturation inhibitory protein from urine of pregnant women: N-terminal sequence homology with human nonsecretory ribonuclease.". Chem. Pharm. Bull. 39 (1): 146–9. PMID 2049798.
- Mizuta K, Awazu S, Yasuda T, Kishi K (1990). "Purification and characterization of three ribonucleases from human kidney: comparison with urine ribonucleases.". Arch. Biochem. Biophys. 281 (1): 144–51. doi:10.1016/0003-9861(90)90424-W. PMID 2383019.
- Beintema JJ, Blank A, Schieven GL, et al. (1989). "Differences in glycosylation pattern of human secretory ribonucleases.". Biochem. J. 255 (2): 501–5. PMC 1135256. PMID 3202829. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1135256.
- Beintema JJ, Wietzes P, Weickmann JL, Glitz DG (1984). "The amino acid sequence of human pancreatic ribonuclease.". Anal. Biochem. 136 (1): 48–64. doi:10.1016/0003-2697(84)90306-3. PMID 6201087.
- Russo N, de Nigris M, Ciardiello A, et al. (1995). "Expression in mammalian cells, purification and characterization of recombinant human pancreatic ribonuclease.". FEBS Lett. 369 (2-3): 352. doi:10.1016/0014-5793(95)96890-G. PMID 7649283.
- Seno M, Futami J, Kosaka M, et al. (1994). "Nucleotide sequence encoding human pancreatic ribonuclease.". Biochim. Biophys. Acta 1218 (3): 466–8. PMID 8049276.
- Yasuda T, Nadano D, Takeshita H, Kishi K (1994). "Two distinct secretory ribonucleases from human cerebrum: purification, characterization and relationships to other ribonucleases.". Biochem. J. 296 (3): 617–25. PMC 1137742. PMID 8280059. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1137742.
- Papageorgiou AC, Shapiro R, Acharya KR (1997). "Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution.". EMBO J. 16 (17): 5162–77. doi:10.1093/emboj/16.17.5162. PMC 1170149. PMID 9311977. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170149.
- Klink TA, Woycechowsky KJ, Taylor KM, Raines RT (2000). "Contribution of disulfide bonds to the conformational stability and catalytic activity of ribonuclease A.". Eur. J. Biochem. 267 (2): 566–72. doi:10.1046/j.1432-1327.2000.01037.x. PMID 10632727.
- Pous J, Canals A, Terzyan SS, et al. (2000). "Three-dimensional structure of a human pancreatic ribonuclease variant, a step forward in the design of cytotoxic ribonucleases.". J. Mol. Biol. 303 (1): 49–60. doi:10.1006/jmbi.2000.4506. PMID 11021969.
- Pous J, Mallorquí-Fernández G, Peracaula R, et al. (2001). "Three-dimensional structure of human RNase 1 delta N7 at 1.9 A resolution.". Acta Crystallogr. D Biol. Crystallogr. 57 (Pt 4): 498–505. doi:10.1107/S0907444901001147. PMID 11264578.
- Gaur D, Swaminathan S, Batra JK (2001). "Interaction of human pancreatic ribonuclease with human ribonuclease inhibitor. Generation of inhibitor-resistant cytotoxic variants.". J. Biol. Chem. 276 (27): 24978–84. doi:10.1074/jbc.M102440200. PMID 11342552.
- Futami J, Maeda T, Kitazoe M, et al. (2001). "Preparation of potent cytotoxic ribonucleases by cationization: enhanced cellular uptake and decreased interaction with ribonuclease inhibitor by chemical modification of carboxyl groups.". Biochemistry 40 (25): 7518–24. doi:10.1021/bi010248g. PMID 11412105.
- Canals A, Pous J, Guasch A, et al. (2002). "The structure of an engineered domain-swapped ribonuclease dimer and its implications for the evolution of proteins toward oligomerization.". Structure 9 (10): 967–76. doi:10.1016/S0969-2126(01)00659-1. PMID 11591351.
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