Eosinophil-derived neurotoxin
Wikipedia on Answers.com:
Top
Eosinophil-derived neurotoxin
| Ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 PDB rendering based on 1gqv. |
|||||||||||||
|
|||||||||||||
| Identifiers | |||||||||||||
| Symbols | RNASE2; EDN; RNS2 | ||||||||||||
| External IDs | OMIM: 131410 MGI: 1858238 HomoloGene: 121614 GeneCards: RNASE2 Gene | ||||||||||||
| EC number | 3.1.27.5 | ||||||||||||
|
|||||||||||||
| RNA expression pattern | |||||||||||||
 |
|||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 6036 | 93726 | |||||||||||
| Ensembl | ENSG00000169385 | ENSMUSG00000047222 | |||||||||||
| UniProt | P10153 | n/a | |||||||||||
| RefSeq (mRNA) | NM_002934.2 | NM_053113.2 | |||||||||||
| RefSeq (protein) | NP_002925.1 | NP_444343.2 | |||||||||||
| Location (UCSC) | Chr 14: 21.42 – 21.42 Mb |
Chr 14: 51.87 – 51.88 Mb |
|||||||||||
| PubMed search | [1] | [2] | |||||||||||
Non-secretory ribonuclease is an enzyme that in humans is encoded by the RNASE2 gene.[1][2][3]
The protein encoded by this gene is found in eosinophil granulocytes.
|
Contents
|
References
- ^ Mastrianni DM, Eddy RL, Rosenberg HF, Corrette SE, Shows TB, Tenen DG, Ackerman SJ (Jun 1992). "Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14". Genomics 13 (1): 240–2. doi:10.1016/0888-7543(92)90237-M. PMID 1577491.
- ^ Rosenberg HF, Tenen DG, Ackerman SJ (Jul 1989). "Molecular cloning of the human eosinophil-derived neurotoxin: a member of the ribonuclease gene family". Proc Natl Acad Sci U S A 86 (12): 4460–4. doi:10.1073/pnas.86.12.4460. PMC 287289. PMID 2734298. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=287289.
- ^ "Entrez Gene: RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6036.
Further reading
- Rosenberg HF, Domachowske JB (2000). "Eosinophils, ribonucleases and host defense: solving the puzzle.". Immunol. Res. 20 (3): 261–74. doi:10.1007/BF02790409. PMID 10741866.
- Abu-Ghazaleh RI, Dunnette SL, Loegering DA, et al. (1993). "Eosinophil granule proteins in peripheral blood granulocytes.". J. Leukoc. Biol. 52 (6): 611–8. PMID 1464733.
- Sakakibara R, Hashida K, Kitahara T, Ishiguro M (1992). "Characterization of a unique nonsecretory ribonuclease from urine of pregnant women.". J. Biochem. 111 (3): 325–30. PMID 1587793.
- Hamann KJ, Ten RM, Loegering DA, et al. (1990). "Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily.". Genomics 7 (4): 535–46. doi:10.1016/0888-7543(90)90197-3. PMID 2387583.
- Hamann KJ, Barker RL, Loegering DA, et al. (1990). "Sequence of human eosinophil-derived neurotoxin cDNA: identity of deduced amino acid sequence with human nonsecretory ribonucleases.". Gene 83 (1): 161–7. doi:10.1016/0378-1119(89)90414-9. PMID 2591744.
- Barker RL, Loegering DA, Ten RM, et al. (1989). "Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases.". J. Immunol. 143 (3): 952–5. PMID 2745977.
- Beintema JJ, Hofsteenge J, Iwama M, et al. (1988). "Amino acid sequence of the nonsecretory ribonuclease of human urine.". Biochemistry 27 (12): 4530–8. doi:10.1021/bi00412a046. PMID 3166997.
- Sorrentino S, Tucker GK, Glitz DG (1988). "Purification and characterization of a ribonuclease from human liver.". J. Biol. Chem. 263 (31): 16125–31. PMID 3182786.
- Gleich GJ, Loegering DA, Bell MP, et al. (1986). "Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease.". Proc. Natl. Acad. Sci. U.S.A. 83 (10): 3146–50. doi:10.1073/pnas.83.10.3146. PMC 323469. PMID 3458170. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=323469.
- Niwata Y, Ohgi K, Sanda A, et al. (1985). "Purification and properties of bovine kidney ribonucleases.". J. Biochem. 97 (3): 923–34. PMID 3926759.
- de Beer T, Vliegenthart JF, Löffler A, Hofsteenge J (1995). "The hexopyranosyl residue that is C-glycosidically linked to the side chain of tryptophan-7 in human RNase Us is alpha-mannopyranose.". Biochemistry 34 (37): 11785–9. doi:10.1021/bi00037a016. PMID 7547911.
- Hofsteenge J, Müller DR, de Beer T, et al. (1994). "New type of linkage between a carbohydrate and a protein: C-glycosylation of a specific tryptophan residue in human RNase Us.". Biochemistry 33 (46): 13524–30. doi:10.1021/bi00250a003. PMID 7947762.
- Kardana A, Bagshawe KD, Coles B, et al. (1993). "Characterisation of UGP and its relationship with beta-core fragment.". Br. J. Cancer 67 (4): 686–92. doi:10.1038/bjc.1993.127. PMC 1968365. PMID 8471426. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1968365.
- Mosimann SC, Newton DL, Youle RJ, James MN (1996). "X-ray crystallographic structure of recombinant eosinophil-derived neurotoxin at 1.83 A resolution.". J. Mol. Biol. 260 (4): 540–52. doi:10.1006/jmbi.1996.0420. PMID 8759319.
- Krieg J, Hartmann S, Vicentini A, et al. (1998). "Recognition signal for C-mannosylation of Trp-7 in RNase 2 consists of sequence Trp-x-x-Trp.". Mol. Biol. Cell 9 (2): 301–9. PMC 25254. PMID 9450956. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=25254.
- Sur S, Glitz DG, Kita H, et al. (1998). "Localization of eosinophil-derived neurotoxin and eosinophil cationic protein in neutrophilic leukocytes.". J. Leukoc. Biol. 63 (6): 715–22. PMID 9620664.
- Zhang J, Rosenberg HF (2001). "Sequence variation at two eosinophil-associated ribonuclease loci in humans.". Genetics 156 (4): 1949–58. PMC 1461363. PMID 11102386. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1461363.
|
||||||||||||||||||||||||||||
See also
External links
 |
This article on a gene on chromosome 14 is a stub. You can help Wikipedia by expanding it. |
|
||||||||||||||||||||||||
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
Post a question - any question - to the WikiAnswers community:
Copyrights:
Wikipedia on Answers.com
This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article Eosinophil-derived neurotoxin.
Read more