Ro10-5824

Ro10-5824

Systematic (IUPAC) name
2-methyl-5-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]pyrimidin-4-amine
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	189744-46-5
ATC code	?
PubChem	CID 16759175
Chemical data
Formula	C17H20N4
Mol. mass	280.367 g/mol
SMILES	eMolecules & PubChem
Y (what is this?)  (verify)

Ro10-5824 is a drug which acts as a dopamine receptor partial agonist selective for the D₄ subtype, and has nootropic effects in animal studies.^[1][2]

References

1. ^ Powell SB, Paulus MP, Hartman DS, Godel T, Geyer MA (March 2003). "RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice". Neuropharmacology 44 (4): 473–81. doi:10.1016/S0028-3908(02)00412-4. PMID 12646284. 
2. ^ Newman-Tancredi A, Heusler P, Martel JC, Ormière AM, Leduc N, Cussac D (May 2008). "Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K+ channel modulation in transfected cells". The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 11 (3): 293–307. doi:10.1017/S1461145707008061. PMID 17897483. 

v t e Dopaminergics   Receptor ligands Agonists Adamantanes: Amantadine Memantine Rimantadine; Aminotetralins: 7-OH-DPAT 8-OH-PBZI Rotigotine UH-232; Benzazepines: 6-Br-APB Fenoldopam SKF-38,393 SKF-77,434 SKF-81,297 SKF-82,958 SKF-83,959; Ergolines: Bromocriptine Cabergoline Dihydroergocryptine Lisuride LSD Pergolide; Dihydrexidine derivatives: 2-OH-NPA A-86,929 Ciladopa Dihydrexidine Dinapsoline Dinoxyline Doxanthrine; Others: A-68,930 A-77636 A-412,997 ABT-670 ABT-724 Aplindore Apomorphine Aripiprazole Bifeprunox BP-897 CY-208,243 Dizocilpine Etilevodopa Flibanserin Ketamine Melevodopa Modafinil Pardoprunox Phencyclidine PD-128,907 PD-168,077 PF-219,061 Piribedil Pramipexole Propylnorapomorphine Pukateine Quinagolide Quinelorane Quinpirole RDS-127 Ro10-5824 Ropinirole Rotigotine Roxindole Salvinorin A SKF-89,145 Sumanirole Terguride Umespirone WAY-100,635 Antagonists Typical antipsychotics: Acepromazine Azaperone Benperidol Bromperidol Clopenthixol Chlorpromazine Chlorprothixene Droperidol Flupentixol Fluphenazine Fluspirilene Haloperidol Loxapine Mesoridazine Methotrimeprazine Nemonapride Penfluridol Perazine Periciazine Perphenazine Pimozide Prochlorperazine Promazine Sulforidazine Sulpiride Sultopride Thioridazine Thiothixene Trifluoperazine Triflupromazine Trifluperidol Zuclopenthixol; Atypical antipsychotics: Amisulpride Asenapine Blonanserin Cariprazine Carpipramine Clocapramine Clorotepine Clozapine Gevotroline Iloperidone Lurasidone Melperone Molindone Mosapramine Olanzapine Paliperidone Perospirone Piquindone Quetiapine Remoxipride Risperidone Sertindole Tiospirone Ziprasidone Zotepine; Antiemetics: AS-8112 Alizapride Bromopride Clebopride Domperidone Metoclopramide Thiethylperazine; Others: Amoxapine Buspirone Butaclamol Ecopipam EEDQ Eticlopride Fananserin L-745,870 Nafadotride Nuciferine PNU-99,194 Raclopride Sarizotan SB-277,011-A SCH-23,390 SKF-83,959 Sonepiprazole Spiperone Spiroxatrine Stepholidine Tetrahydropalmatine Tiapride UH-232 Yohimbine   Reuptake inhibitors Plasmalemmal DAT inhibitors Piperazines: DBL-583 GBR-12,935 Nefazodone Vanoxerine; Piperidines: BTCP Desoxypipradrol Dextromethylphenidate Difemetorex Ethylphenidate Methylnaphthidate Methylphenidate Phencyclidine Pipradrol; Pyrrolidines: Diphenylprolinol Methylenedioxypyrovalerone (MDPV) Naphyrone Prolintane Pyrovalerone; Tropanes: β-CPPIT Altropane Brasofensine CFT Cocaine Dichloropane Difluoropine FE-β-CPPIT FP-β-CPPIT Ioflupane (123I) Iometopane RTI-112 RTI-113 RTI-121 RTI-126 RTI-150 RTI-177 RTI-229 RTI-336 Tenocyclidine Tesofensine Troparil Tropoxane WF-11 WF-23 WF-31 WF-33; Others: Adrafinil Armodafinil Amfonelic acid Amineptine Benzatropine (Benztropine) Bromantane BTQ BTS-74,398 Bupropion (Amfebutamone) Ciclazindol Diclofensine Dimethocaine Diphenylpyraline Dizocilpine DOV-102,677 DOV-21,947 DOV-216,303 Etybenzatropine (Ethylbenztropine) EXP-561 Fencamine Fencamfamine Fezolamine GYKI-52,895 Indatraline Ketamine Lefetamine Levophacetoperane LR-5182 Manifaxine Mazindol Medifoxamine Mesocarb Modafinil Nefopam Nomifensine NS-2359 O-2172 Pridefrine Propylamphetamine Radafaxine SEP-225,289 SEP-227,162 Sertraline Sibutramine Tametraline Tedatioxetine Tripelennamine Vesicular VMAT inhibitors Deserpidine Ibogaine Reserpine Tetrabenazine   Releasing agents Morpholines: Fenbutrazate Morazone Phendimetrazine Phenmetrazine; Oxazolines: 4-Methylaminorex (4-MAR, 4-MAX) Aminorex Clominorex Cyclazodone Fenozolone Fluminorex Pemoline Thozalinone; Phenethylamines (also amphetamines, cathinones, phentermines, etc): 2-Hydroxyphenethylamine (2-OH-PEA) 4-CAB 4-Methylamphetamine (4-MA) 4-Methylmethamphetamine (4-MMA) Alfetamine Amfecloral Amfepentorex Amfepramone Amphetamine (Dextroamphetamine Levoamphetamine) Amphetaminil β-Methylphenethylamine (β-Me-PEA) Benzodioxolylbutanamine (BDB) Benzodioxolylhydroxybutanamine (BOH) Benzphetamine Buphedrone Butylone Cathine Cathinone Clobenzorex Clortermine D-Deprenyl Dimethoxyamphetamine (DMA) Dimethoxymethamphetamine (DMMA) Dimethylamphetamine Dimethylcathinone (Dimethylpropion, metamfepramone) Ethcathinone (Ethylpropion) Ethylamphetamine Ethylbenzodioxolylbutanamine (EBDB) Ethylone Famprofazone Fenethylline Fenproporex Flephedrone Fludorex Furfenorex Hordenine Lophophine (Homomyristicylamine) Mefenorex Mephedrone Methamphetamine (Desoxyephedrine, Methedrine; Dextromethamphetamine Levomethamphetamine) Methcathinone (Methylpropion) Methedrone Methoxymethylenedioxyamphetamine (MMDA) Methoxymethylenedioxymethamphetamine (MMDMA) Methylbenzodioxolylbutanamine (MBDB) Methylenedioxyamphetamine (MDA, tenamfetamine) Methylenedioxyethylamphetamine (MDEA) Methylenedioxyhydroxyamphetamine (MDOH) Methylenedioxymethamphetamine (MDMA) Methylenedioxymethylphenethylamine (MDMPEA, homarylamine) Methylenedioxyphenethylamine (MDPEA, homopiperonylamine) Methylone Ortetamine Parabromoamphetamine (PBA) Parachloroamphetamine (PCA) Parafluoroamphetamine (PFA) Parafluoromethamphetamine (PFMA) Parahydroxyamphetamine (PHA) Paraiodoamphetamine (PIA) Paredrine (Norpholedrine, Oxamphetamine) Phenethylamine (PEA) Pholedrine Phenpromethamine Prenylamine Propylamphetamine Tiflorex (Flutiorex) Tyramine (TRA) Xylopropamine Zylofuramine; Piperazines: 2,5-Dimethoxy-4-bromobenzylpiperazine (2C-B-BZP) Benzylpiperazine (BZP) Methoxyphenylpiperazine (MeOPP, paraperazine) Methylbenzylpiperazine (MBZP) Methylenedioxybenzylpiperazine (MDBZP, piperonylpiperazine); Others: 2-Amino-1,2-dihydronaphthalene (2-ADN) 2-Aminoindane (2-AI) 2-Aminotetralin (2-AT) 4-Benzylpiperidine (4-BP) 5-IAI Clofenciclan Cyclopentamine Cypenamine Cyprodenate Feprosidnine Gilutensin Heptaminol Hexacyclonate Indanylaminopropane (IAP) Indanorex Isometheptene Methylhexanamine Naphthylaminopropane (NAP) Octodrine Phthalimidopropiophenone Propylhexedrine (Levopropylhexedrine) Tuaminoheptane (Tuamine)   Allosteric modulators Quinazolinamines: SoRI-9804 SoRI-20040 SoRI-20041   Enzyme inhibitors Anabolism PAH inhibitors 3,4-Dihydroxystyrene TH inhibitors 3-Iodotyrosine Aquayamycin Bulbocapnine Metirosine Oudenone AAAD/DDC inhibitors Benserazide Carbidopa Genistein Methyldopa Catabolism MAO inhibitors Nonselective: Benmoxin Caroxazone Echinopsidine Furazolidone Hydralazine Indantadol Iproclozide Iproniazid Isocarboxazid Isoniazid Linezolid Mebanazine Metfendrazine Nialamide Octamoxin Paraxazone Phenelzine Pheniprazine Phenoxypropazine Pivalylbenzhydrazine Procarbazine Safrazine Tranylcypromine; MAO-A selective: Amiflamine Bazinaprine Befloxatone Befol Brofaromine Cimoxatone Clorgiline Esuprone Harmala alkaloids Methylene Blue Metralindole Minaprine Moclobemide Pirlindole Sercloremine Tetrindole Toloxatone Tyrima; MAO-B selective: D-Deprenyl L-Deprenyl (Selegiline) Ladostigil Lazabemide Milacemide Pargyline Rasagiline Safinamide COMT inhibitors Entacapone Tolcapone DBH inhibitors Disulfiram Dopastin Fusaric acid Nepicastat Tropolone   Others Precursors L-Phenylalanine → L-Tyrosine → L-DOPA (Levodopa) Cofactors Ferrous iron (Fe2+) Tetrahydrobiopterin Vitamin B3 (Niacin Nicotinamide → NADPH) Vitamin B6 (Pyridoxine Pyridoxamine Pyridoxal → Pyridoxal phosphate) Vitamin B9 (Folic acid → Tetrahydrofolic acid) Vitamin C (Ascorbic acid) Zinc (Zn2+) Others Activity enhancers: Benzofuranylpropylaminopentane (BPAP) Phenylpropylaminopentane (PPAP); Toxins: Oxidopamine (6-Hydroxydopamine) List of dopaminergic drugs

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