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Ro67-4853

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Ro67-4853

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Ro67-4853
Systematic (IUPAC) name
butyl (9H-xanthene-9-carbonyl)carbamate
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
ATC code  ?
PubChem CID 9949202
IUPHAR ligand 1387
Chemical data
Formula C19H19NO4 
Mol. mass 325.358 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Ro67-4853 is a drug used in scientific research, which acts as a selective positive allosteric modulator for the metabotropic glutamate receptor subtype mGluR1.[1][2][3] It was derived by modification of the simpler compound Ro01-6128, and has itself subsequently been used as a lead compound to develop a range of potent and selective mGluR1 positive modulators.[4][5]

References

  1. ^ Knoflach F, Mutel V, Jolidon S, Kew JN, Malherbe P, Vieira E, Wichmann J, Kemp JA (November 2001). "Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site". Proceedings of the National Academy of Sciences of the United States of America 98 (23): 13402–7. doi:10.1073/pnas.231358298. PMC 60883. PMID 11606768. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=60883. 
  2. ^ Hemstapat K, de Paulis T, Chen Y, Brady AE, Grover VK, Alagille D, Tamagnan GD, Conn PJ (August 2006). "A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators". Molecular Pharmacology 70 (2): 616–26. doi:10.1124/mol.105.021857. PMID 16645124. 
  3. ^ Sheffler DJ, Conn PJ (September 2008). "Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells". Neuropharmacology 55 (4): 419–27. doi:10.1016/j.neuropharm.2008.06.047. PMC 2600811. PMID 18625258. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2600811. 
  4. ^ Vieira E, Huwyler J, Jolidon S, Knoflach F, Mutel V, Wichmann J (October 2005). "9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers". Bioorganic & Medicinal Chemistry Letters 15 (20): 4628–31. doi:10.1016/j.bmcl.2005.05.135. PMID 16099654. 
  5. ^ Vieira E, Huwyler J, Jolidon S, Knoflach F, Mutel V, Wichmann J (March 2009). "Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers". Bioorganic & Medicinal Chemistry Letters 19 (6): 1666–9. doi:10.1016/j.bmcl.2009.01.108. PMID 19233648. 


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