Parkway Village, Memphis
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Parkway Village, Memphis
| Receptor tyrosine kinase-like orphan receptor 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | ROR1; MGC99659; NTRKR1; dJ537F10.1 | ||||||||||||
| External IDs | OMIM: 602336 MGI: 1347520 HomoloGene: 3675 GeneCards: ROR1 Gene | ||||||||||||
| EC number | 2.7.10.1 | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 4919 | 26563 | |||||||||||
| Ensembl | ENSG00000185483 | ENSMUSG00000035305 | |||||||||||
| UniProt | Q01973 | Q9Z139 | |||||||||||
| RefSeq (mRNA) | NM_001083592.1 | NM_013845.4 | |||||||||||
| RefSeq (protein) | NP_001077061.1 | NP_038873.2 | |||||||||||
| Location (UCSC) | Chr 1: 64.24 – 64.65 Mb |
Chr 4: 99.77 – 100.12 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Tyrosine-protein kinase transmembrane receptor ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is an enzyme that in humans is encoded by the ROR1 gene.[1][2][3] ROR1 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family.
Function
The protein encoded by this gene is a receptor tyrosine kinase that modulates neurite growth in the central nervous system. It is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors.[1]
References
- ^ a b "Entrez Gene: receptor tyrosine kinase-like orphan receptor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4919.
- ^ Masiakowski P, Carroll RD (December 1992). "A novel family of cell surface receptors with tyrosine kinase-like domain". J. Biol. Chem. 267 (36): 26181–90. PMID 1334494.
- ^ Reddy UR, Phatak S, Pleasure D (October 1996). "Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains". Oncogene 13 (7): 1555–9. PMID 8875995.
Further reading
- Reddy UR, Phatak S, Allen C, et al. (1997). "Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis.". Genomics 41 (2): 283–5. doi:10.1006/geno.1997.4653. PMID 9143508.
- Rose JE, Behm FM, Drgon T, et al.. "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.". Mol. Med. 16 (7-8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2896464.
- Nomi M, Oishi I, Kani S, et al. (2001). "Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases.". Mol. Cell. Biol. 21 (24): 8329–35. doi:10.1128/MCB.21.24.8329-8335.2001. PMID 11713269.
- Baskar S, Kwong KY, Hofer T, et al. (2008). "Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia.". Clin. Cancer Res. 14 (2): 396–404. doi:10.1158/1078-0432.CCR-07-1823. PMID 18223214.
- Shabani M, Asgarian-Omran H, Omran HA, et al. (2007). "Overexpression of orphan receptor tyrosine kinase Ror1 as a putative tumor-associated antigen in Iranian patients with acute lymphoblastic leukemia.". Tumour Biol. 28 (6): 318–26. doi:10.1159/000121405. PMID 18354269.
- Daneshmanesh AH, Mikaelsson E, Jeddi-Tehrani M, et al. (2008). "Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy.". Int. J. Cancer 123 (5): 1190–5. doi:10.1002/ijc.23587. PMID 18546292.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Smith EN, Bloss CS, Badner JA, et al. (2009). "Genome-wide association study of bipolar disorder in European American and African American individuals.". Mol. Psychiatry 14 (8): 755–63. doi:10.1038/mp.2009.43. PMID 19488044.
- Paganoni S, Ferreira A (2005). "Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2.". J. Cell. Sci. 118 (Pt 2): 433–46. doi:10.1242/jcs.01622. PMID 15654020.
- Shabani M, Asgarian-Omran H, Vossough P, et al. (2008). "Expression profile of orphan receptor tyrosine kinase (ROR1) and Wilms' tumor gene 1 (WT1) in different subsets of B-cell acute lymphoblastic leukemia.". Leuk. Lymphoma 49 (7): 1360–7. doi:10.1080/10428190802124000. PMID 18604725.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Fukuda T, Chen L, Endo T, et al. (2008). "Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a.". Proc. Natl. Acad. Sci. U.S.A. 105 (8): 3047–52. doi:10.1073/pnas.0712148105. PMID 18287027.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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