ROS1
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ROS1 (gene)
Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ROS1 gene.[1][2]
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.[2]
Interactions
ROS1 (gene) has been shown to interact with PTPN6.[3]
References
- ^ Galland F, Stefanova M, Lafage M, Birnbaum D (July 1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenet Cell Genet 60 (2): 114–6. doi:10.1159/000133316. PMID 1611909.
- ^ a b "Entrez Gene: ROS1 v-ros UR2 sarcoma virus oncogene homolog 1 (avian)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6098.
- ^ Keilhack, H; Müller M, Böhmer S A, Frank C, Weidner K M, Birchmeier W, Ligensa T, Berndt A, Kosmehl H, Günther B, Müller T, Birchmeier C, Böhmer F D (January 2001). "Negative Regulation of Ros Receptor Tyrosine Kinase Signaling: An Epithelial Function of the Sh2 Domain Protein Tyrosine Phosphatase Shp-1". J. Cell Biol. (United States) 152 (2): 325–34. doi:10.1083/jcb.152.2.325. ISSN 0021-9525. PMC 2199605. PMID 11266449. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2199605.
Further reading
- Birchmeier C, O'Neill K, Riggs M, Wigler M (1990). "Characterization of ROS1 cDNA from a human glioblastoma cell line". Proc. Natl. Acad. Sci. U.S.A. 87 (12): 4799–803. doi:10.1073/pnas.87.12.4799. PMC 54205. PMID 2352949. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=54205.
- Sharma S, Birchmeier C, Nikawa J et al (1990). "Characterization of the ros1-gene products expressed in human glioblastoma cell lines". Oncogene Res. 5 (2): 91–100. PMID 2691958.
- Birchmeier C, Sharma S, Wigler M (1988). "Expression and rearrangement of the ROS1 gene in human glioblastoma cells". Proc. Natl. Acad. Sci. U.S.A. 84 (24): 9270–4. doi:10.1073/pnas.84.24.9270. PMC 299735. PMID 2827175. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=299735.
- Matsushime H, Wang LH, Shibuya M (1987). "Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule". Mol. Cell. Biol. 6 (8): 3000–4. PMC 367872. PMID 3023956. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=367872.
- Satoh H, Yoshida MC, Matsushime H et al (1987). "Regional localization of the human c-ros-1 on 6q22 and flt on 13q12". Jpn. J. Cancer Res. 78 (8): 772–5. PMID 3115921.
- Birchmeier C, Birnbaum D, Waitches G et al (1986). "Characterization of an activated human ros gene". Mol. Cell. Biol. 6 (9): 3109–16. PMC 367045. PMID 3785223. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=367045.
- Sonnenberg-Riethmacher E, Walter B, Riethmacher D et al (1996). "The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis". Genes Dev. 10 (10): 1184–93. doi:10.1101/gad.10.10.1184. PMID 8675006.
- Zeng L, Sachdev P, Yan L et al (2001). "Vav3 Mediates Receptor Protein Tyrosine Kinase Signaling, Regulates GTPase Activity, Modulates Cell Morphology, and Induces Cell Transformation". Mol. Cell. Biol. 20 (24): 9212–24. doi:10.1128/MCB.20.24.9212-9224.2000. PMC 102179. PMID 11094073. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=102179.
- Keilhack H, Müller M, Böhmer SA et al (2001). "Negative Regulation of Ros Receptor Tyrosine Kinase Signaling: An Epithelial Function of the Sh2 Domain Protein Tyrosine Phosphatase Shp-1". J. Cell Biol. 152 (2): 325–34. doi:10.1083/jcb.152.2.325. PMC 2199605. PMID 11266449. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2199605.
- Charest A, Kheifets V, Park J et al (2003). "Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 916–21. doi:10.1073/pnas.242741799. PMC 298701. PMID 12538861. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=298701.
- Charest A, Lane K, McMahon K et al (2003). "Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)". Genes Chromosomes Cancer 37 (1): 58–71. doi:10.1002/gcc.10207. PMID 12661006.
- Mungall AJ, Palmer SA, Sims SK et al (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Légaré C, Sullivan R (2005). "Expression and localization of c-ros oncogene along the human excurrent duct". Mol. Hum. Reprod. 10 (9): 697–703. doi:10.1093/molehr/gah087. PMID 15235104.
- Biskup C, Böhmer A, Pusch R et al (2005). "Visualization of SHP-1-target interaction". J. Cell. Sci. 117 (Pt 21): 5165–78. doi:10.1242/jcs.01397. PMID 15456853.
- Girish V, Sachdeva N, Minz RW et al (2006). "Bcl2 and ROS1 expression in human meningiomas: an analysis with respect to histological subtype". Indian journal of pathology & microbiology 48 (3): 325–30. PMID 16761743.
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