Roxana (
rŏksăn'ə) or
Roxane (
-săn'ē), d. 311 B.C., wife of
Alexander the Great. She was the daughter of Oxyartes, a Bactrian baron, and Alexander married her (327) to consolidate his power in Persia. She and Alexander's posthumous son, Alexander IV, were, after Alexander's death, embroiled in the wars of the
Diadochi and were imprisoned by
Cassander at Amphipolis in Macedonia. They were later killed.