RPD may refer to:
- RPD, Ruchnoy Pulemyot Degtyaryova, a Soviet-made light machine gun
- Raccoon Police Department, from the Resident Evil video games
- Recognition primed decision, a decision-making model
- Removable partial denture, a dental prosthesis for the partially edentulous patient
- Relative percent difference, a statistical measure of deviation between two measurements
- RNase PH domain, an exoribonuclease domain in certain enzymes
- Robot programming by demonstration, a technique to teach new skills to robots
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