Rune, from Proto-Norse runa "secret", can refer to:
- A letter from one of the Runic alphabets, formerly used to write Germanic languages
(see also Runology).
- A Rune stone
- A Scandinavian given name.
- A letter from the Orkhon script or the Old Hungarian script, also called "runiform".
- In popular culture
- Rune (computer game), by Human Head Studios from 2000.
- Rune Caster, a Dreamcast RPG game from Japan.
- Rune (film), by RUNE, LLC / ISIS Productions from 2006.
- A comicbook villain, Rune (comics)
- A version of Honda Goldwing motorcycles.
- Leo's (Kimba the White Lion grown up) son in Jungle Emperor Leo
- Led Zeppelin IV is sometimes called "Runes"
- In the game RuneScape, either a rare metal or a small stone used for casting spells.
- an item in Diablo II: Lord of Destruction.
- A term used for magics in Suikoden series.
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