Sabretooth or sabertooth can refer to:
- Saber-toothed cat, several prehistoric felines
- Saber-toothed tigers, Smilodon, an ancient genus of cats
- Sabertooth fish, a deep-sea fish found in the tropics
- Sabre-toothed blenny, a variety of fish that lives even deeper underwater in the benthic zone
- San Jose SaberCats, an Arena Football League team
- Sabretooth (mascot), the mascot for the Buffalo Sabres National Hockey League team
- Sabertooth salmon, Oncorhynchus rastrosus, an ancient species of salmon
- Sabretooth (comics), a Marvel Comics supervillain
- Sabretooth (movie), a 2002 made-for-TV movie
- Sabre-Tooth, a 1966 book by Peter O'Donnell featuring the character Modesty Blaise
- SABERTOOTH, a protein sequence and structure alignment algorithm
- Sabertooth, a French hardcore band.
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