Great sadness in 3 words can be said as "I am sullen".
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Fear, anger, sadness.
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grief and sadness
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The word "sadness" is in the King James Version of the Bible one
time. It is in Ecclesiastes 7:3, "Sorrow [is] better than laughter:
for by the sadness of the countenance the heart is made better."
Please see the related link below.
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Several words that mean "great sadness" that have the letter "o"
in the middle are gloomy, morose and sorrowful. You could also use
"despondent."