Scalpel may mean:
- Scalpel, a surgical instrument used for cutting
- Laser scalpel, a scalpel which uses a laser, not a blade, for cutting
- SS-24 Scalpel, an intercontinental ballistic missile
- SCALPEL, a system that uses electron beams to print features atoms wide on microchips
- Scalpel (Transformers), a fictional character.
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