Scram may refer to:
- Scram (or SCRAM), an emergency shutdown of a nuclear reactor or a complex operation.
- Scram is a slang term, probably of American (U.S.) origin, meaning "to depart at once". It is typically used by one person telling another to "scram", equivalent to saying "Get out of here". Probably an abbreviation of scramble.
- Scram cannon, a hypothetical kinetic energy weapon based on ram accelerator technology.
- Scram (computer game), the name of two computer games based around shutdown of a nuclear reactor.
- Scram drive, a hard drive (or any other data storage device) containing sensitive information and stored in a convenient location, which is easily removable and transportable in case of rapid evacuation.
- Scramjet, a type of jet engine where the flow of the air and combustion of the fuel air mixture through the engine happen at supersonic speeds.
- Scram, a journal of unpopular culture, is a Los Angeles-based music and arts publication founded in 1992.
- Scram Jones, a songwriter and record producer.
- Scram is also the name of a Transformer toy, one of the Generation 2 Autobots.
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