Seleucia

The port city of classical Antioch, located at the mouth of the Orontes River; now Suediah, in Turkey. Enjoying the dual advantages of a virtually impregnable acropolis and a superior natural harbor, the site was occupied continuously from at least 2000 B.C. In the 8th century B.C. it developed as a prosperous emporium, colonized largely by Greeks. In 301 B.C. it passed to Seleucus I Nicator, a general of Alexander the Great and the eponymous founder of the Seleucid dynasty. Seleucus refounded the site, its name reflecting his intention of establishing it as the capital of his newly enlarged empire. Upon his death in 281/0 B.C., however, this distinction was transferred to antioch, some 16 miles (26 km) inland, and Seleucia reverted to the position of mercantile harbor and port-of-entry for the capital.

As such it served as the port from which Barnabas and Paul set out on the first missionary journey and, though not mentioned specifically, it was certainly via Seleucia that they returned to Antioch (Acts 14:26) and set out a second time (Acts 15:39-41). The city continued to serve the larger community of Antioch, until the latter's decline in the 6th century.

Concordance
Acts 13:4