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serine racemase
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| Identifiers | |
| Symbol | SRR |
| Entrez | 63826 |
| HUGO | 14398 |
| OMIM | 606477 |
| RefSeq | NM_021947 |
| UniProt | Q9GZT4 |
| Other data | |
| EC number | 5.1.1.16 |
| Locus | Chr. 17 p13 |
Serine racemase is an enzyme which generates D-serine from L-serine. D-serine acts as a neuronal signaling molecule by activating NMDA receptors in the brain. In humans, the serine racemase protein is encoded by the SRR gene.[1]
Mammalian serine racemase is a pyridoxal 5'-phosphate dependent enzyme that catalyzes both the racemization of L-serine to D-serine and also the elimination of water from L-serine, generating pyruvate and ammonia.[2] The enzyme is physiologically stimulated by divalent cations (e.g., magnesium) and is allosterically activated by the magnesium/ATP complex.
References
- ^ De Miranda J, Santoro A, Engelender S, Wolosker H (October 2000). "Human serine racemase: moleular cloning, genomic organization and functional analysis". Gene 256 (1-2): 183–8. PMID 11054547.
- ^ De Miranda J, Panizzutti R, Foltyn VN, Wolosker H (October 2002). "Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14542–7. doi:. PMID 12393813.
External links
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