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SERPINB1

 
Wikipedia: SERPINB1
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Serpin peptidase inhibitor, clade B (ovalbumin), member 1
Identifiers
Symbols SERPINB1; EI; ELANH2; LEI; M/NEI; MNEI; PI2
External IDs OMIM: 130135 MGI: 1913472 HomoloGene: 69399
RNA expression pattern
PBB GE SERPINB1 213572 s at tn.png
PBB GE SERPINB1 212268 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1992 66222
Ensembl ENSG00000021355 n/a
UniProt P30740 n/a
RefSeq NM_030666 (mRNA) NM_025429 (mRNA)
NP_109591 (protein) NP_079705 (protein)
Location Chr 6:
2.78 - 2.79 Mb		 n/a
PubMed search [1] [2]

Leukocyte elastase inhibitor is an enzyme that in humans is encoded by the SERPINB1 gene.[1][2]


Contents

See also

References

  1. ^ Remold-O'Donnell E, Chin J, Alberts M (Jul 1992). "Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor". Proc Natl Acad Sci U S A 89 (12): 5635-9. PMID 1376927. 
  2. ^ "Entrez Gene: SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1992. 

Further reading

  • Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.". Electrophoresis 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667. 
  • Packard BZ, Lee SS, Remold-O'Donnell E, Komoriya A (1995). "A serpin from human tumor cells with direct lymphoid immunomodulatory activity: mitogenic stimulation of human tumor-infiltrating lymphocytes.". Biochim. Biophys. Acta 1269 (1): 41–50. doi:10.1016/0167-4889(95)00113-7. PMID 7578269. 
  • Sugimori T, Cooley J, Hoidal JR, Remold-O'Donnell E (1995). "Inhibitory properties of recombinant human monocyte/neutrophil elastase inhibitor.". Am. J. Respir. Cell Mol. Biol. 13 (3): 314–22. PMID 7654387. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Evans E, Cooley J, Remold-O'Donnell E (1996). "Characterization and chromosomal localization of ELANH2, the gene encoding human monocyte/neutrophil elastase inhibitor.". Genomics 28 (2): 235–40. doi:10.1006/geno.1995.1136. PMID 8530031. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Zeng W, Silverman GA, Remold-O'Donnell E (1998). "Structure and sequence of human M/NEI (monocyte/neutrophil elastase inhibitor), an Ov-serpin family gene.". Gene 213 (1-2): 179–87. doi:10.1016/S0378-1119(98)00189-9. PMID 9630619. 
  • Sun J, Stephens R, Mirza G, et al. (1999). "A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes.". Cytogenet. Cell Genet. 82 (3-4): 273–7. doi:10.1159/000015118. PMID 9858835. 
  • Perani P, Zeggai S, Torriglia A, Courtois Y (2000). "Mutations on the hinge region of leukocyte elastase inhibitor determine the loss of inhibitory function.". Biochem. Biophys. Res. Commun. 274 (3): 841–4. doi:10.1006/bbrc.2000.3191. PMID 10924364. 
  • Cooley J, Takayama TK, Shapiro SD, et al. (2002). "The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites.". Biochemistry 40 (51): 15762–70. doi:10.1021/bi0113925. PMID 11747453. 
  • Korkmaz B, Attucci S, Hazouard E, et al. (2002). "Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates.". J. Biol. Chem. 277 (42): 39074–81. doi:10.1074/jbc.M202918200. PMID 12114510. 
  • Benarafa C, Cooley J, Zeng W, et al. (2003). "Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1).". J. Biol. Chem. 277 (44): 42028–33. doi:10.1074/jbc.M207080200. PMID 12189154. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ahmed M, Forsberg J, Bergsten P (2005). "Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry.". J. Proteome Res. 4 (3): 931–40. doi:10.1021/pr050024a. PMID 15952740. 

External links

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Serpins
inhibitory
Cross class inhibitory
MENT · SCCA-1 · crmA
noninhibitory

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