SERPINB4

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Serpin peptidase inhibitor, clade B (ovalbumin), member 4
Identifiers
Symbols	SERPINB4; SCCA1; LEUPIN; PI11; SCCA-2; SCCA2
External IDs	OMIM: 600518 MGI: 3573933 HomoloGene: 74456
Gene ontology Molecular function • serine-type endopeptidase inhibitor activity Cellular component • extracellular region • cytoplasm Biological process • immune response • regulation of proteolysis
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6318	20248
Ensembl	ENSG00000057149	n/a
UniProt	P48594	n/a
RefSeq	NM_002974 (mRNA)	NM_009126 (mRNA)
	NP_002965 (protein)	NP_033152 (protein)
Location	Chr 18: 59.46 - 59.46 Mb	n/a
PubMed search	[1]	[2]

Serpin B4 is a protein that in humans is encoded by the SERPINB4 gene.^[1][2][3]

Contents 1 See also 2 References 3 Further reading 4 External links

See also

• Serpin

References

1. ^ Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, Hui SM, Silverman GA (May 1995). "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene". Proc Natl Acad Sci U S A 92 (8): 3147-51. PMID 7724531. 
2. ^ Sakata Y, Arima K, Takai T, Sakurai W, Masumoto K, Yuyama N, Suminami Y, Kishi F, Yamashita T, Kato T, Ogawa H, Fujimoto K, Matsuo Y, Sugita Y, Izuhara K (Feb 2004). "The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1". J Biol Chem 279 (7): 5081-7. doi:10.1074/jbc.M311585200. PMID 14630915. 
3. ^ "Entrez Gene: SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6318. 

Further reading

• Barnes RC, Worrall DM (1995). "Identification of a novel human serpin gene; cloning sequencing and expression of leupin.". FEBS Letters 373 (1): 61–5. doi:10.1016/0014-5793(95)01015-7. PMID 7589435. 
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Bartuski AJ, Kamachi Y, Schick C, et al. (1999). "A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases". Genomics 54 (2): 297–306. doi:10.1006/geno.1998.5586. PMID 9828132. 
• Sakaguchi Y, Kishi F, Murakami A, et al. (1999). "Structural analysis of human SCC antigen 2 promoter". Biochim. Biophys. Acta 1444 (1): 111–6. PMID 9931463. 
• Cataltepe S, Gornstein ER, Schick C, et al. (2000). "Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas". J. Histochem. Cytochem. 48 (1): 113–22. PMID 10653592. 
• Luke C, Schick C, Tsu C, et al. (2000). "Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage". Biochemistry 39 (24): 7081–91. doi:10.1021/bi000050g. PMID 10852705. 
• Uemura Y, Pak SC, Luke C, et al. (2000). "Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells". Int. J. Cancer 89 (4): 368–77. doi:10.1002/1097-0215(20000720)89:4<368::AID-IJC9>3.0.CO;2-6. PMID 10956412. 
• Hamada K, Shinomiya H, Asano Y, et al. (2001). "Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter". Biochim. Biophys. Acta 1518 (1-2): 124–31. PMID 11267667. 
• Takeda A, Kajiya A, Iwasawa A, et al. (2003). "Aberrant expression of serpin squamous cell carcinoma antigen 2 in human tumor tissues and cell lines: evidence of protection from tumor necrosis factor-mediated apoptosis". Biol. Chem. 383 (7-8): 1231–6. doi:10.1515/BC.2002.136. PMID 12437110. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
• Gariboldi M, Peissel B, Fabbri A, et al. (2003). "SCCA2-like serpins mediate genetic predisposition to skin tumors". Cancer Res. 63 (8): 1871–5. PMID 12702576. 
• Pontisso P, Calabrese F, Benvegnù L, et al. (2004). "Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma". Br. J. Cancer 90 (4): 833–7. doi:10.1038/sj.bjc.6601543. PMID 14970861. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
• Ray R, Choi M, Zhang Z, et al. (2005). "Uteroglobin suppresses SCCA gene expression associated with allergic asthma". J. Biol. Chem. 280 (11): 9761–4. doi:10.1074/jbc.C400581200. PMID 15677460. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Sueoka K, Nawata S, Nakagawa T, et al. (2005). "Tumor-associated serpin, squamous cell carcinoma antigen stimulates matrix metalloproteinase-9 production in cervical squamous cell carcinoma cell lines". Int. J. Oncol. 27 (5): 1345–53. PMID 16211231. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
• Katagiri C, Nakanishi J, Kadoya K, Hibino T (2006). "Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase". J. Cell Biol. 172 (7): 983–90. doi:10.1083/jcb.200508064. PMID 16549498. 

External links

• MeSH SERPINB4+protein,+human

This article on a gene on chromosome 18 is a stub. You can help Wikipedia by expanding it. v • d • e

v • d • e Serpins inhibitory Alpha 1-antichymotrypsin · Alpha 1-antitrypsin · Alpha 2-antiplasmin · Antithrombin · C1-inhibitor · Heparin cofactor II · Protein C inhibitor · Plasminogen activator inhibitor-1 · Plasminogen activator inhibitor-2 · Protein Z-related protease inhibitor SERPINA1 · SERPINA2 · SERPINA3 · SERPINA4 · SERPINA5 · SERPINA6 · SERPINA7 · SERPINA8 · SERPINA9 SERPINB1 · SERPINB2 · SERPINB3 · SERPINB4 · SERPINB5 · SERPINB6 · SERPINB7 · SERPINB8 · SERPINB9 · SERPINB13 SERPINC1 · SERPIND1 · SERPINE1 · SERPINE2 · SERPINE2 · SERPINF1 · SERPING1 · SERPINH1 · SERPINI1 · SERPINI2 Cross class inhibitory MENT · SCCA-1 · crmA noninhibitory Heat shock protein 47 · Maspin · Ovalbumin · SERPINF1 · Thyroxine-binding globulin · Transcortin · SERPINF1

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