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Sevelamer

 
Drug Info: Sevelamer

Brand names: RenaGel®

Chemical formula:



Sevelamer carbonate (Renvela™) tablets

What are Sevelamer carbonate (Renvela™) tablets?

SEVELAMER is a polymer. It binds phosphates in the stomach and prevents them from being absorbed into the body. This medicine is used in patients with Chronic Kidney Disease on dialysis to prevent dangerous increases in phosphates.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• difficulty swallowing
• bowel obstruction
• stomach surgery or disorder
• an unusual or allergic reaction to sevelamer, medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should this medicine be used?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take with meals. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What drug(s) may interact with Sevelamer?

Do not take this medicine with any of the following medications:
• phosphorus containing product or supplement

Due to its binding capacity in the stomach, sevelamer could possibly interact with any of the following medicines. If you are taking any of these medicines, take them at least one hour before or 3 hours after you take sevelamer.
• antibiotics
• medicines for an irregular heartbeat
• levothyroxine and other thyroid hormones
• seizure (convulsion) medications
• theophylline
warfarin

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking Sevelamer?

Visit your Doctor or health care professional for regular check ups. Follow the diet as directed by your doctor.

If you are taking other medications, take them at least 1 hour before or 3 hours after taking this medicine.

What side effects may I notice from receiving Sevelamer?

Side effects that you should report to your doctor or health care professional as soon as possible:
• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• confusion, irritability
• difficulty breathing
• fever, infection
• new or worsening constipation
• unusually weak or tired
• vomiting

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
• cough
• diarrhea
• headache
• pain
• stomach upset, nausea

Where can I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture. Throw away any unused medicine after the expiration date.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

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Wikipedia: Sevelamer
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Sevelamer
Systematic (IUPAC) name
poly(allylamine-
co-N,N'-diallyl-1,3-diamino-2-hydroxypropane)
Identifiers
CAS number 52757-95-6
ATC code V03AE02
PubChem 3085017
DrugBank APRD01226
Chemical data
Formula [(C3H7N)a+b.(C9H17N2O)c]m
where a+b:c = 9:1
Mol. mass variable
Pharmacokinetic data
Bioavailability nil
Metabolism nil
Half life n/a
Excretion faecal 100%
Therapeutic considerations
Pregnancy cat.

B3 (Australia), C (US)

Legal status

Schedule 4 (Australia), Rx only (US)

Routes oral

Sevelamer (rINN) (pronounced /sɛˈvɛləmər, sɛˈvɛləmɪər/) is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. When taken with meals, sevelamer binds to dietary phosphate and prevents its absorption. It is marketed by Genzyme under the trade names Renagel and Renvela (carbonate formulation).

Contents

Chemistry and pharmacology

Sevelamer is a copolymer of 2-(chloromethyl)oxirane (epichlorohydrin) and prop-2-en-1-amine. The marketed form sevelamer hydrochloride is a partial hydrochloride salt being present as approximately 40% amine hydrochloride and 60% sevelamer base. The amine groups of sevelamer become partially protonated in the intestine and interact with phosphorus molecules through ionic and hydrogen bonding.

Clinical use

Indications

Sevelamer is indicated for the management of hyperphosphataemia in adult patients with stage 4 and 5 chronic renal failure on hemodialysis.

Contraindications

Sevelamer therapy is contraindicated in hypophosphataemia or bowel obstruction.

Adverse effects

Common adverse drug reactions (ADRs) associated with the use of sevelamer include: hypotension, hypertension, nausea and vomiting, dyspepsia, diarrhea, flatulence, and/or constipation.

Other effects

Sevelamer can significantly reduce serum uric acid.[1] This reduction has no known detrimental effect and several beneficial effects, including reducing hyperuricemia, uric acid nephrolithiasis, and gout.

External links

References

  1. ^ Garg JP, Chasan-Taber S, Blair A, et al. (January 2005). "Effects of sevelamer and calcium-based phosphate binders on uric acid concentrations in patients undergoing hemodialysis: a randomized clinical trial". Arthritis and rheumatism 52 (1): 290–5. doi:10.1002/art.20781. PMID 15641045. 

 
 
Learn More
Sevelamer carbonate (Renvela™) tablets
Sevelamer Carbonate Oral tablet
Sevelamer Hydrochloride Oral capsule

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