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Sigma-Aldrich

 
Hoover's Profile: Sigma-Aldrich Corporation
(NASDAQ (GS):SIAL)
Company Financials
Income Statement
Balance Sheet
Cash Flow Statement

Contact Information
Sigma-Aldrich Corporation
3050 Spruce St.
St. Louis, MO 63103
MO Tel. 314-771-5765
Fax 314-771-5757

Type: Public
On the web: http://www.sigmaaldrich.com
Employees: 7,862
Employee growth: 7.7%

Check the shelves of any research (or mad) scientist and you're likely to find Sigma-Aldrich's chemical products. The company is a leading supplier of chemicals to research laboratories. It has nearly 90,000 customers, including labs involved in government and commercial research, for its more than 100,000 chemical and 30,000 equipment products. The products are divided into three categories: research chemicals (further divided into essentials and specialties), fine chemicals (for commercial applications), and biotech products (for immunochemical and molecular biology applications). The company operates in 35 countries, sells its wares worldwide, and manufactures about half of its chemical products itself.

Key numbers for fiscal year ending December, 2008:
Sales: $2,200.7M
One year growth: 7.9%
Net income: $341.5M
Income growth: 9.8%

Officers:
Chairman: David R. Harvey
President, CEO, and Director: Jai P. Nagarkatti
VP, CFO, and Secretary: Rakesh Sachdev

Competitors:
Bayer AG
Brenntag
VWR International

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Company News: Sigma-Aldrich
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Company History: Sigma-Aldrich Corporation
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Incorporated: 1975
NAIC: 325188 All Other Inorganic Chemical Manufacturing; 325199 All Other Basic Organic Chemical Manufacturing; 325413 In-Vitro Diagnostic Substance Manufacturing; 325414 Biological Product (Except Diagnostic) Manufacturing; 325998 All Other Miscellaneous Chemical Product and Preparation Manufacturing; 422210 Drugs and Druggist Sundries Wholesalers; 422690 Other Chemical and Allied Products Wholesalers; 454111 Electronic Shopping; 454113 Mail-Order Houses; 541710 Research and Development in the Physical, Engineering, and Life Sciences
SIC: 2869 Industrial Organic Chemicals Nec; 2835 Diagnostic Substances; 2836 Biological Products Except Diagnostic; 2899 Chemical Preparations Nec; 5961 Catalog & Mail-Order Houses; 8731 Commercial Physical Research; 8733 Noncommercial Research Organizations

Sigma-Aldrich Corporation is a developer, manufacturer, and distributor of a wide range of biochemicals, organic chemicals, chromatography products, diagnostic reagents, and laboratory equipment and kits. The company is the world's leading seller of chemicals to research laboratories, pharmaceutical companies, and hospitals, with a product line that includes approximately 100,000 substances and 30,000 equipment products sold principally under five well-known chemical brands: Sigma, Aldrich, Fluka, Riedel-de Haën, and Supelco. Of these 100,000 substances, roughly 46,000 of them are manufactured by the company, and the company-manufactured products account for around 60 percent of overall sales. Sigma-Aldrich has more than 70,000 customers in more than 165 countries; more than 70 percent of its sales to these customers are on the small side, averaging about $400. About 60 percent of sales are generated outside the United States. The company maintains manufacturing facilities in Missouri, California, Connecticut, Florida, Illinois, Kansas, Massachusetts, New Jersey, Ohio, Pennsylvania, Texas, Wisconsin, Australia, Canada, France, Germany, India, Ireland, Israel, Japan, Singapore, Switzerland, and the United Kingdom.

Born Through a 1975 Merger

Sigma-Aldrich Corporation is the result of a 1975 merger between two specialty chemical companies, one that manufactured biochemicals (Sigma Chemical Company) and another that manufactured organic chemicals (Aldrich Chemical Company, Inc.). While offering divergent products, both companies regarded high-quality products and customer service a priority. The merger, therefore, represented a convergence of business strategy as well as the creation of a diversified product line that ranked Sigma-Aldrich at the top of the specialty chemical industry. In particular, because of the scientific community's involvement in the growing field of biomedical research, Sigma-Aldrich's product catalog became standard issue in pharmaceutical laboratories around the world.

Sigma Chemical Company was started in 1945 in St. Louis. At a time when sugar was scarce, Dan Broida, a biochemist, began a storefront business to manufacture saccharin. The company later went on to produce biochemicals and diagnostic products. Sigma's customers ranged from hospitals to university laboratories. Scientific fields concerned with the study of life sciences, as well as disease diagnostics, use biochemicals as the basic substances to develop pharmaceuticals and diagnostic tests.

Aldrich Chemical Company, founded by the Harvard-educated chemist Dr. Alfred R. Bader, began manufacturing organic chemicals in a Milwaukee garage six years after Broida established Sigma. Aldrich's first products were those chemicals not offered by Eastman Kodak Company, a leader in the chemical industry. Bader soon decided that his company could engage in direct competition with larger companies, and he began offering a broad line of organics sold to research laboratories of pharmaceutical companies. The company did exceedingly well and its customer list soon included Abbott Laboratories and Ciba-Geigy Ltd., among others.

The 1975 merger between the two companies matched skill for skill and talent for talent. Broida assumed the role of chairman and Bader took the position of company president. While the combined company interests still remained small compared to those of the larger industry firms, the business acumen of Sigma-Aldrich's management went a long way in securing an impressive percentage of the specialty chemical research market. By 1979 the company laid claim to between 30 and 40 percent of the $100 million research market. Sales climbed to $68 million, representing an annual increase of 15 percent. Earnings jumped 24 percent to $9.2 million, causing Wall Street analysts to predict continued growth of 20 percent a year.

Sigma-Aldrich's marketing success, achieved by neither a large sales force nor expensive advertising outlays, relied on the distribution of catalogs. In addition to advertising products available on a phone-order basis, the catalog offered detailed information about the physical properties of the marketed chemicals. The value of the catalog as a reference source as well as an advertising tool was evident, and it soon became a company trademark. Initially compiled by Bader in the early 1950s as a one-page, one-chemical listing, the catalog grew to include 40,000 chemicals by the late 1970s. Sigma-Aldrich's small sales force distributed 300,000 free copies of the catalog in 1979.

The company's reputation among chemists as a manufacturer of quality products matched a distribution network that ensured most orders would be filled in 24 hours. Interestingly enough, in the early years of Sigma-Aldrich's business an average order amounted to less than $100. This indicated a customer profile of academicians or laboratory researchers experimenting with relatively small quantities of chemicals. Although this profile was altered somewhat in the ensuing years because of the increasing pressure to supply bulk commercial chemicals, Sigma-Aldrich fiercely defended its business as first and foremost a service to the research community.

Overseas expansion in the late 1970s found 125 countries purchasing Sigma-Aldrich's products with company subsidiaries operating in Canada, the United Kingdom, Japan, Germany, and Israel. Nearly 40 percent of sales in 1979 resulted from overseas business.

Explosive Growth

In the 1980s the company's growth matched the explosion in the U.S. biomedical research market. Despite such gains Sigma-Aldrich's management, much to the chagrin of some industry analysts, refused to alter the strategy that laid the framework for previous company growth. Rather than set long-term goals or exploit the bulk chemical market as some observers suggested, Broida defended his company's straightforward "opportunistic" policy of keeping pace with state-of-the-art developments in the scientific fields of immunology, microbiology, and endocrinology. By supplying chemicals in small quantities to research centers, Sigma-Aldrich's growth and profits corresponded to breakthrough research in the development of pharmaceuticals from recombinant DNA.

Wall Street analysts also criticized the company's B-Line Systems, Inc., subsidiary, which had been inherited from the Sigma side of the company lineage. Manufacturing metal frameworks for industrial plants, the subsidiary was criticized for competing in the business of specialty chemicals on the one hand, and for contributing small profit margins on the other. Despite such criticism, however, the company's lack of long-term debt, its sparkling earnings record, and its annual profit increase of 20 to 25 percent mitigated the seriousness of such complaints.

Upon Dan Broida's death in 1981 several changes in policy and management affected the company structure. Tom Cori, a nine-year Sigma veteran, became company president. Common stock, formerly controlled by a 50 percent insiders interest, became more widely held. In 1985, 2.2 million of the 8.68 million outstanding shares were sold for $129.5 million. Most of this stock had been held by relatives of Broida, and the sale reduced their holdings to 1.3 million shares. This figure represented approximately the same interest held by the Bader family.

Of the 2.2 million shares sold the company purchased 500,000. Apparently Bader had been opposed to the company purchase partially on the grounds that $13 million was borrowed to finance the transaction. Company debts totaled $32.4 million in short-term loans due in part to a $16 million expansion program started in 1980. Some five million shares, on the other hand, were estimated to be available for trade in the over-the-counter market. Price per share between July and September 1985 ranged from $60.50 to $71, well over the company's $14 per share book value. A three-for-one stock split was soon in order.

Acquisition of Fluka and Creation of Fine Chemicals Division

By 1986 some 1.5 million company catalogs circulated yearly. Sigma-Aldrich's orders continued to average less than $150 each; on the other hand company profits totaled $29 million on volume of $215 million. Although president of a company with such impressive achievements, Cori did not rest on his laurels. Limited governmental funds for scientific research as well as the effect of the strong dollar on overseas sales offered some cause for concern. To facilitate expansion by broadening Sigma-Aldrich's product line, the company purchased Pathfinder Laboratories. The new subsidiary, costing $1.5 million in stock during 1984, manufactured radioactive chemicals. A much larger acquisition came in 1989 when Sigma-Aldrich purchased one of its main European competitors, Switzerland-based Fluka Chemie AG, from Ciba-Geigy and F. Hoffmann-La Roche Ltd. Fluka, maker of biochemicals and organic chemicals for the laboratory market, had annual sales of about $55 million.

In 1991 Sigma-Aldrich took a significant step toward filling more bulk orders through the establishment of a fine chemicals division, which was charged with large-scale manufacturing of chemicals for the pharmaceutical and biopharmaceutical industries. That same year, Bader retired from his position as chairman and was named chairman emeritus. Cori took on the additional title of chairman.

Bader's new role was short-lived, however, as in early 1992 he was voted off the board of directors and stripped of his chairman emeritus title. The reason for the board's action was never made public, although it was speculated to involve either an allegation that Bader had made a bet against the company's stock through a call option, a charge Bader denied, or the fact that Bader had failed to report his exercising of the option to the Securities and Exchange Commission in a timely manner, an action that Bader said had been "an honest mistake." In any event, Bader, who was held in high esteem by numerous Sigma-Aldrich customers on six continents, continued to be one of the largest holders of the company's stock into the early 21st century, when he held about 6 percent.

Acquisitions of Supelco (1993) and Riedel-de Haën (1997)

While sales and earnings growth slowed in the early and mid-1990s to 15 percent or less per year, Sigma-Aldrich continued to expand aggressively through such internal growth initiatives as the adding of manufacturing and distribution capacity as well as through acquisitions. In May 1993 the company acquired Supelco, Inc., from Rohm and Haas Company for $54.7 million. Based in Bellefonte, Pennsylvania, Supelco was a worldwide supplier of chromatography products used to analyze and purify drugs and had annual sales of $48 million. In 1994 David R. Harvey was named president and chief operating officer, with Cori remaining chairman and CEO.

In the area of plant expansion, Sigma-Aldrich by 1997 had three new manufacturing facilities up and running: the first in St. Louis specializing in industrial tissue culture products, the second in the United Kingdom for pharmaceutical intermediates, and the third in Israel for immunochemicals. Meantime, in 1996, the company was fined $480,000 by the federal government for illegally exporting toxic substances that could be used to make chemical weapons; Sigma-Aldrich said that it had "inadvertently violated" U.S. export laws and that there was no evidence that the substances had actually been used to make such weapons.

Acquisitions returned to the fore in the late 1990s. In June 1997 the company purchased a 75 percent interest in Riedel-de Haën, a German maker of laboratory chemicals. In March 1999 Sigma-Aldrich purchased the remaining 25 percent. In December 1998 the company stepped up its presence in the biotechnology sector with the $39.5 million purchase of Texas-based Genosys Biotechnologies, Inc., one of the world's leading suppliers of custom synthetic DNA products, essential components of gene research.

Restructuring and Divestment of B-Line

In spite of the company's acquisition drive, growth slowed to a trickle by 1998, when sales increased by just 6 percent and net income barely edged ahead, increasing by only 0.1 percent. During 1999, a year in which the company was proceeding in a similar direction, significant changes took place at Sigma-Aldrich. In October, Harvey was promoted to president and CEO, with Cori remaining chairman. One month later, Harvey announced that the company would launch a major restructuring and would sell its noncore B-Line Systems subsidiary.

Through the restructuring, Sigma-Aldrich was reorganized into four main business units: laboratory products, which focused on chemicals used for research conducted in academia and industry and which accounted for about 55 percent of the company's revenues; life sciences, which concentrated on specific areas of research, including molecular biology, immunochemistry, cell biology, and chromatography (20 percent of sales); fine chemicals, which was retooled to include both large-scale manufacturing of chemicals and custom manufacturing (15 percent of sales); and diagnostics, which focused on products used to help diagnose and treat diseases, with a particular emphasis on tests in the areas of coagulation and immunoassay (10 percent). Sigma-Aldrich also planned to drive growth through e-commerce, having successfully launched an award-winning web site in September 1998 through which 5 percent of U.S. orders were being placed by the end of 1999. With the completion in May 2000 of the sale of B-Line Systems to Cooper Industries, Inc., for $425 million, Sigma-Aldrich could, for the first time in its history, plan for the future as a company with a single focus, supplying chemicals for the life sciences and high-technology markets.

In the wake of the B-Line Systems divestiture, Sigma-Aldrich pursued sales gains in part by pursuing modest acquisitions. In 2000, for example, the company purchased ARK Scientific GmbH Biosystems, a German oligonucleotide producer; First Medical, Inc., a diagnostic immunoassay developer based in Mountain View, California; and Amelung GmbH, a German maker of coagulation instrumentation. In February 2001 Sigma-Aldrich spent $37.2 million for Isotec, Inc., of Miamisburg, Ohio, a producer of stable isotopes and isotopically labeled compounds used in life science research, medical diagnostics, and PET imaging applications. In a major investment in the future, Sigma-Aldrich in late 2001 opened a new $55 million research and development facility in St. Louis for its biotechnology unit (formerly the life sciences unit). In the meantime, Cori retired at the end of 2000 and Harvey added the chairmanship to his duties.

In the most significant development of 2002, Sigma-Aldrich announced plans to divest its poorly performing diagnostics division, which was generating only a little more than 6 percent of overall revenues. Completed by April 2003, the divestment left the company with three strong business units: scientific research, biotechnology, and fine chemicals. Each of these units had their own R&D, manufacturing, and sales operations. Late in 2002 Sigma-Aldrich agreed to pay a $1.76 million fine to the federal government for exporting without a license a biological chemical with weapons potential. The case involved Research Biochemicals, Inc., a firm Sigma-Aldrich had acquired in 1997.

Increasing Emphasis on Fine Chemicals

Since the restructuring launched in 1999, the fine chemicals unit had gained greater prominence. Seeking to change its image as simply a supplier of laboratory chemicals, Sigma-Aldrich moved aggressively to raise its profile in custom manufacturing. Toward this end, the company in 2004 completed two key acquisitions: Ultrafine, a leading supplier of contract chemical manufacturing services for drug development based in Manchester, England; and Madison, Wisconsin-based Tetrionics, a producer of high-potency cytotoxic (cell-killing) active pharmaceutical ingredients. To further heighten the profile of its fine chemicals unit, Sigma-Aldrich late in 2004 rebranded the business SAFC (standing for Sigma-Aldrich Fine Chemicals).

SAFC was boosted from a top-25 global position in fine chemicals into the top ten via the $366.8 million, February 2005 purchase of the JRH Biosciences division of the Australian firm CSL Limited, the largest acquisition in Sigma-Aldrich's history. Based in the Kansas City suburb of Lenexa, Kansas, JRH specialized in the production of cell cultures and serums used in the development and manufacturing of biopharmaceuticals. JRH's sales for 2004 totaled $150 million. The acquisition of JRH pushed SAFC's 2005 sales to $437 million, or approximately 26 percent of Sigma-Aldrich's total revenues of $1.67 billion.

The year 2005 was significant for several other developments. The acquisition of Proligo Group in April bolstered Sigma-Aldrich's position in research tools for the rapidly growing field of genomics. Boulder, Colorado-based Proligo, a firm with 2004 sales of $40 million that was acquired from Degussa AG, supplied custom DNA, custom RNA, and certain raw materials used in DNA and RNA synthesis. In another reorganization announced in July 2005, Sigma-Aldrich split its scientific research and biotechnology units into three units, each serving a distinct market segment: Research Essentials, responsible for high-volume sales of chemicals to pharmaceutical, academic, and research clients; Research Specialties, offering thousands of products via print and online catalogs, primarily to individual scientists; and Research Biotech, developer of innovative products for life-science research. SAFC was unaffected by this reorganization into an overarching four-unit structure. Finally, at the end of the year, Harvey retired as CEO while remaining chairman. Taking over the management reins was Jai Nagarkatti, a 29-year company veteran who had worked his way up from chemist to president and COO, the latter position attained in August 2004.

Launch of New Strategic Plan in 2006

Revenues grew steadily throughout the initial years of the 21st century, reaching a record $1.8 billion by 2006. The net income of $276.8 million for that year was another best-ever figure. During the year a new strategic plan was launched that, in addition to completing the reorganization announced the previous July, involved four other initiatives: expanding in the faster-growing markets of Canada, Latin America, and the Asia-Pacific region; strengthening the firm's e-commerce channels; implementing process improvement actions to increase profitability; and propelling future growth via strategic and bolt-on acquisitions.

Among the moves made into markets outside the United States and Europe, Sigma-Aldrich in July 2006 opened a state-of-the-art pharmaceutical chemical laboratory in Bangalore, India. Earlier that year, the company bought its largest distributor in China, Beijing Superior Chemicals and Instruments Company, Ltd., and also established a wholly foreign owned enterprise in that nation, Sigma-Aldrich (Shanghai) Trading Co. Ltd. Sigma-Aldrich completed three other strategic acquisitions in 2006: the Iropharm unit of Honeywell International Inc., which operated a plant in Arklow, Ireland, where active pharmaceutical ingredients were produced; Pharmorphix Limited of Cambridge, England, a provider of research services to pharmaceutical and biotech customers; and Advanced Separation Technologies, Inc. (Astec), a Whippany, New Jersey, concern specializing in the development of chemicals used in separating and/or analyzing complex mixtures.

This acquisition spree continued in 2007 with the February purchase for $60 million of Epichem Group Limited, a British maker of chemicals for the semiconductor and solar panel industries that was integrated into SAFC. In line with its strategic plan, Sigma-Aldrich increasingly focused on markets outside the United States and Europe to help reach its goal of annual sales growth of 10 percent. In September 2007 the company announced plans to build a new multipurpose manufacturing and warehousing campus in Wuxi, China. On the Internet front, meantime, Sigma-Aldrich by the third quarter of 2007 had met another goal: increasing web-based ordering for its three research-based units to more than 40 percent of overall sales.

Principal Subsidiaries

Sigma-Aldrich Co.; Aldrich Chemical Company, Inc.; Sigma-Aldrich B.V. (Netherlands); Sigma-Aldrich Chemie GmbH (Germany); Proligo International GmbH (Germany); Sigma-Aldrich Chemie Verwaltungs GmbH (Germany); Sigma-Aldrich Grundsteucks Verwaltungs GmbH & Co. KG (Germany); Sigma-Aldrich Chimie S.N.C. (France); Supelco, Inc.; Advanced Separation Technologies, Inc.; Sigma-Aldrich Biotechnology Holding Co., Inc.; Sigma-Aldrich Research Biochemicals, Inc.; Sigma-Aldrich, Inc.; Sigma-Aldrich Finance Co.; Sigma-Aldrich Chemie GmbH (Switzerland); Sigma-Aldrich Production GmbH (Switzerland); Sigma-Aldrich N.V./S.A. (Belgium); Sigma-Aldrich Chemie B.V. (Netherlands); Sigma-Aldrich Italia S.r.l. (Italy); Sigma-Aldrich (Shanghai) Trading Co. Ltd. (China); Sigma-Aldrich Denmark A/S; Sigma-Aldrich Finland Oy; Sigma-Aldrich Norway AS; Sigma-Aldrich Sweden AB; Sigma-Aldrich Company, Ltd. (U.K.); SAFC Biosciences Limited (U.K.); Pharmorphix Limited (U.K.); Sigma-Aldrich Handels GmbH (Austria); Sigma-Aldrich spol.s.r.o. (Czech Republic); Sigma-Aldrich (O M) Ltd. (Greece); Sigma-Aldrich Kft (Hungary); Sigma-Aldrich Financial Services Limited (Ireland); Sigma-Aldrich Ireland Ltd.; Sigma-Aldrich Sp. z.o.o. (Poland); Sigma-Aldrich Quimica S.A. (Spain); Sigma-Aldrich de Argentina S.A.; Sigma-Aldrich Pty., Limited (Australia); Sigma-Aldrich Oceania Pty. Limited (Australia); Sigma-Aldrich New Zealand Ltd.; SAFC Biosciences Pty. Ltd. (Australia); Sigma-Aldrich Quimica Brasil Ltda. (Brazil); Sigma-Aldrich Canada Ltd.; Sigma-Aldrich Chemicals Private Ltd. (India); Sigma-Aldrich Japan KK; Sigma-Aldrich Korea Ltd.; Sigma-Aldrich Quimica S.A. de C.V. (Mexico); Sigma-Aldrich Pte. Ltd. (Singapore); Sigma-Aldrich (M) Sdn. Bhd. (Malaysia); Sigma-Aldrich Pty. Ltd. (South Africa); Silverberry Limited (Ireland); Shrawdine Limited (Ireland); Sigma-Aldrich Ireland Ltd.; SAFC, Inc.; SAFC Biosciences, Inc.

Principal Divisions

Research Essentials; Research Specialties; Research Biotech; SAFC.

Principal Competitors

Merck KGaA; General Electric Company; Evonik Degussa GmbH; BASF Aktiengesellschaft; Royal DSM N.V.; Applied Biosystems Group; Thermo Fisher Scientific, Inc.; Roche Holding Ltd.; Invitrogen Corporation; Tyco International Ltd.; Lonza Group Ltd.; Wako Chemicals USA, Inc.; VWR International Inc.; Millipore Corporation; Qiagen N.V.

Further Reading

Bader, Alfred, Adventures of a Chemist Collector, London: Weidenfeld and Nicolson, 1995, 288 p.

Boswell, Clay, "Sigma-Aldrich Expands SAFC," Chemical Market Reporter, January 24, 2005, pp. 2, 27.

------, "Sigma-Aldrich Set for Global Growth in Pharmaceuticals and Fine Chemicals," Chemical Market Reporter, August 3, 1998, p. 17.

------, "Sigma-Aldrich's New SAFC Aims for Top 10," Chemical Market Reporter, November 1, 2004, pp. 6, 8.

Byrne, Harlan S., "Sigma-Aldrich: The Right Chemistry for Strong Performance," Barron's, May 17, 1993, pp. 47-48.

Corey, Andrea, "Sigma-Aldrich Restructuring, Selling Metals Division," St. Louis Business Journal, February 21, 2000, p. 8.

------, "Web Site Eases Ordering for Sigma-Aldrich Clients," St. Louis Business Journal, February 14, 2000, p. 40.

Desloge, Rick, "Sigma-Aldrich Goes on Acquisition Spree," St. Louis Business Journal, October 13, 2006, pp. 1+.

Dwyer, Joe, III, "Sigma-Aldrich Using Catalog Blitz to Further Market Share," St. Louis Business Journal, March 12, 1990, p. 7A.

Flannery, William, "Sigma-Aldrich Meeting Erupts over Dispute," St. Louis Post-Dispatch, May 6, 1992, p. 1B.

Jarvis, Lisa, "SAFC Forges Ahead," Chemical Market Reporter, November 21/December 4, 2005, pp. 34-35.

------, "Sigma-Aldrich Division Plans $55 Million Research Facility," Chemical Market Reporter, July 10, 2000, p. 5.

Lerner, Matthew, "Sigma-Aldrich Strengthens Role As Pharma Supplier," Chemical Market Reporter, July 7, 1997, p. 14.

Manor, Robert, "Bad Bet?: Sigma-Aldrich Founder Bader Decries Dismissal," St. Louis Post-Dispatch, April 16, 1992, p. 1B.

McCoy, Michael, "Image Improvement at Sigma-Aldrich: Firm's Purchase of Ultrafine Is Part of Profile Raising in Custom Manufacturing," Chemical and Engineering News, May 31, 2004, p. 17.

Melcher, Rachel, "Sigma-Aldrich Buys British Chemical Maker," St. Louis Post-Dispatch, February 13, 2007, p. C2.

------, "Sigma-Aldrich Invests in Biotech," St. Louis Post-Dispatch, September 28, 2007, p. B4.

------, "Sigma-Aldrich Looks to Evolve with Plan," St. Louis Post-Dispatch, November 2, 2005, p. B1.

------, "Sigma-Aldrich Mixes Theory, Magic for Another Reconstruction," St. Louis Post-Dispatch, January 12, 2003, p. E1.

------, "Sigma-Aldrich Tries to Bolster Branding of Fine Chemicals," St. Louis Post-Dispatch, October 26, 2004, p. B1.

Mirasol, Feliza, "SAFC Speeds into New Year," ICIS Chemical Business Americas, January 29/February 4, 2007, pp. 32-34.

------, "Sigma-Aldrich Upgrades Fine Chemicals Operations," Chemical Market Reporter, May 17, 1999, p. 9.

Montgomery, Leland, "Betting on Biotech with Sigma-Aldrich," Financial World, June 11, 1991, pp. 21-22.

Moore, Samuel K., "Sigma-Aldrich Reorganizes Chemicals, Sells Metals Operation," Chemical Week, December 1, 1999, p. 16.

Mullin, Rick, "Sigma-Aldrich: Building a High-Tech Platform," Chemical Week, May 8, 2002, pp. 21-24.

------, "Sigma-Aldrich's New Five-Year Plan," Chemical and Engineering News, February 20, 2006, pp. 20-21.

Ouellette, Jennifer, "CFO Forum: Reorganization Key to Sigma-Aldrich Growth Strategy," Chemical Market Reporter, September 29, 2003, pp. 17-18.

Papanikolaw, Jim, "Sigma-Aldrich Sells Its B-Line Systems to Cooper Industries," Chemical Market Reporter, April 3, 2000, p. 3.

Rothenberg, Eric, "Consistent Chemistry," Financial World, August 9, 1988, p. 42.

Scott, Alex, "Sigma-Aldrich Acquires Custom Manufacturer," Chemical Week, June 30/July 7, 2004, p. 37.

"Sigma-Aldrich: A Little Company Carves a Big Niche," Dun's Review, September 1979, pp. 34+.

"Sigma-Aldrich Buys Proligo for RNA Technology," Chemical Market Reporter, February 21, 2005, p. 2.

Simon, Ruth, "Mail-Order Enzymes," Forbes, May 19, 1986, p. 46.

Stamborski, Al, "Sigma Announces It Will Sell Its Only Non-Life Sciences Business," St. Louis Post-Dispatch, March 28, 2000, p. C7.

Steyer, Robert, "Sigma Sees Sales Doubling in Five Years," St. Louis Post-Dispatch, May 2, 1990, p. 7B.

Thayer, Ann M., "Sigma-Aldrich: Back on Track," Chemical and Engineering News, October 8, 2001, pp. 17-19.

Van Arnum, Patricia, "Sigma-Aldrich Builds Its Position in the Life Sciences Arena," Chemical Market Reporter, June 19, 2000, p. 15.

— Updated by David E. Salamie


Wikipedia: Sigma-Aldrich
Top
Sigma-Aldrich Corporation
Type Public (NASDAQSIAL)
Headquarters United States 3050 Spruce St., St. Louis, Missouri 63103
Key people Jai Nagarkatti, President and CEO
Industry Basic Materials
Products Specialty Chemicals
Revenue $2.2 billion (2008)
Employees >8,000
Website www.sigma-aldrich.com

Sigma-Aldrich Corporation NASDAQSIAL, is a life science and high technology company with over 8,000 employees and operations in 37 countries[1]. Its chemical and biochemical products and kits are used in scientific research, biotechnology, pharmaceutical development, the diagnosis of disease, and as key components in high technology manufacturing[2].

Contents

History

Sigma Chemical Company and Aldrich Chemical Company merged in 1975, producing a current total corporate offering of more than 100,000 chemical products.[3]

Sigma’s early history

The company’s roots spring from 1934 in St. Louis, MO, when two brothers, Aaron Fischer and Bernard Fischlowitz, launched a small consulting firm. The two chemical engineers named their partnership Midwest Consultants – parent company of Sigma Chemical Company – and began to help St. Louis businesses produce a variety of specialty products including cosmetics, shoe dressings, and adhesives and inks for cardboard packaging. The firm incorporated in 1935 and hired Dan Broida, another chemical engineer out of Washington University in St. Louis, to manage the company’s growing consulting and production businesses.

During World War II, Midwest manufactured ammunition components and made felt and paper parts for signal flares. In addition, saccharin was in high demand and short supply. To fill the need, Broida hired new chemists and chemical engineers, gathered equipment (including bathtubs for acid tanks) and formed Sigma Chemical Company as a division of Midwest Consultants. For a year, major distributing companies bought saccharin as fast as Sigma could product it. When the war ended, however, supplies of many raw materials again became plentiful and effectively forced Sigma out of the market.

It its search for a new direction, Sigma’s turn toward research biochemicals came in the form of Lou Berger, a friend of Broida who had completed a MS degree in biochemistry at the Washington University in St. Louis School of Medicine under Nobel Laureates Carl and Gerty Cori. Berger asked if he could occasionally use Sigma’s laboratory. As a graduate student, one of Berger’s tasks had been to extract adenosine triphosphate (ATP) from rabbit muscle. ATP is a major source of energy in living organisms and was used extensively in the Cori’s research.

The Coris and other biomedical researchers at this time were involved in studies requiring ATP in quantity. Berger suggested that Sigma produce the compound on a larger scale and taught his process to Sigma personnel. A small ad in a scientific journal brought orders and Broida expanded production. Within two years, Sigma offered eight additional ATP derivatives and raised purity levels.[3]

In the early 1950s, the world’s leading biochemists gathered in Atlantic City for the Federation Meetings. Sigma exhibited its slim offering of nine products. Nobel-Prize scientists such as Arthur Kornberg, Serva Occhoa and Otto Meyerhoff congratulated Broida on the excellent quality of his products. The exposure propelled Sigma into recognition by the international biochemical research community.[3]

Sigma entered the next decades with broad expansion into biochemicals and clinical products. In 1964, Sigma London was formed to establish a more active position in the market in Great Britain. Two more foreign subsidiaries were formed – Sigma Israel (1970) and Sigma Munich in West Germany (1974).[3]

Aldrich’s early history

Alfred R. Bader, an Austrian immigrant and chemistry graduate student at Harvard University, entertained the idea of starting a company to sell research chemicals in 1949 on the suggestion of the storeroom supervisor at Harvard’s chemistry department. Acting on the premise that chemists needed a wider array of research chemicals and better service, Bader and attorney Jack Eisendrath founded Aldrich Chemical Company in Milwaukee, WI, in 1951[4].

Aldrich offered 1-methyl-3-nitro-1-nitrosofuanidine (MNNG) as it first product, widely used as a methylating reagent. Other products offered in the early 50s include 3-hydroxypyridine, which later became one of Aldrich’s best-selling products; ethyl diazoacetate; tetranitomethane; and ethanedithiol. From 1951 to 1954, Bader developed important collaborations through visits to chemical producers in Europe and the UK. The remainder of the 1950s was characterized by rapid growth in sales and in the number of products offered.

Aldrich’s Rare Chemical Library (RCL) grew out of the collecting and salvaging of valuable research samples of retiring or deceased academic researchers and from other sources. Large-scale contributions of samples to the library have come from such noteworthy chemists as Henry Gilman, George Wittig, Robert Woodward, and Louis and Mary Fieser. RCL has led to the discovery and commercialization by others of some valuable chemical commodities, e.g., Roundup® (Monsanto Co.), based on lead compounds obtained from the RCL.

The late 50s and early 60s witnessed the growing importance of custom synthesis and bulk sales at Aldrich. Over the years, these functions evolved into Sigma-Aldrich Fine Chemicals (SAFC), currently one of four strategic business units within Sigma-Aldrich Corporation.

A significant opportunity in the 1970s came when Professor H. C. Brown of Purdue University asked Aldrich to further develop and commercialize the hydroboration technology and organoborane chemistry that he had developed and patented. This led to the establishment of Aldrich-Boranes, Inc., a wholly owned Aldrich subsidiary created to manufacture hydroboration reagents and products. Some of the first compounds manufactured by Aldrich-Boranes were borane-THF, 9-BBN, and borane-methyl sulfide.[3]

After the merger

Aldrich Chemical Co. merged with Sigma International, Ltd. to form Sigma-Aldrich Corporation in August 1975, when changing trends in chemical research confirmed the synergy to be realized from their complementary product offerings[5]. Annual double-digit growth was the norm in the 80s and 90s, with significant expansion in facilities, major acquisitions and ventures into new market sectors. In December 2000 Sigma-Aldrich launched a strategic plan focusing the Company on “Leadership in Life Science and High Technology.” Other key initiatives on service and process improvements and a strong Internet presence have strengthened Sigma-Aldrich’s current position as a leading technology company.[3]

Other key events

  • 2001 – Acquisition of Isotec[6], a leader in stable isotope production, whose products are used in basic research and the diagnosis of disease; opening of $55 million Life Science and High Technology Center in St. Louis.
  • 2002 – BioInformatics, LLC ranks Sigma-Aldrich first in service, catalogs and Web[7].
  • 2003 – Doubling of US sales force; $57 million investment in production, R&D and warehousing.
  • 2004 – Acquisitions of Ultrafine, a supplier of contract manufacturing services for drug development, and Tetrionics, a producer of high potency and cytotoxic active pharmaceutical ingredients[8].
  • 2005 – Acquisitions of JRH Biosciences[9], a major industrial supplier of cell culture products for the pharmaceutical and biotechnology industries, for $370 million, and the Proligo Group, a global supplier of key genomics research tools; announced membership in The RNAi Consortium and joined leading institutions including MIT, Harvard, and Eli Lilly to develop and distribute genome-wide shRNA libraries globally[10].
  • 2006 – Acquisitions of Beijing Superior Chemicals and Instruments Co.[11], Iropharm, Pharmorphix Ltd.[12], and Advanced Separation Technologies[13]; established a Wholly Foreign Owned Enterprise (WFOE) in China.
  • 2007 – Acquisitions of Epichem Group Ltd.[14] to expand capabilities in materials sciences and semiconductor markets, and Molecular Medicine BioServices to provide large-scale viral manufacturing capabilities; announced alliance with Sangamo BioSciences to develop zinc finger-based laboratory research reagents.
  • 2008 – Introduced Prestige Antibodies® line for proteomics and cell biology research; introduced ChIP kit technology for epigenetic research; Supelco introduced Ascentis® Express HILIC HPLC columns for high-speed, high-efficiency separation; BioInformatics, LLC ranks Sigma-Aldrich first for usefulness and ease-of-use of online and print catalogs.

Key numbers

Key Numbers for Sigma-Aldrich[15].

Revenues: [16]

  • $2.2 billion (2008)

Products:

  • 100,000 chemical products (46,000 manufactured)
  • 30,000 laboratory equipment products

Customers:

  • Approximately one million individual customers worldwide
  • 88,000 accounts

Geographies (% of 2008 sales):

  • United States 35%
  • Europe 43%
  • Canada, Asia Pacific, Latin America 22%

Business Units

Organizational structure aligns to meet the specific needs of four customer segments:[17]

Competitors

Companies in the same biochemical sales sector include Bayer Aktienges Ads, Brenntag Holding GmbH & Co. KG, and VWR International, LLC[18]. For stable isotopically labeled compounds used in biomedical research, competitors include [19] Cambridge Isotope Laboratories, Inc. (CIL)[20] and many more [21]

Management

Sigma-Aldrich Executives[22]

Name Position
Jai Nagarkatti Chairman, President and CEO
Gilles A. Cottier President, SAFC
David W. Julien President, Supply Chain
David A. Smoller President, Research Biotech
Franklin D. Wicks President, Research Specialties and Research Essentials
Karen J. Miller Vice President, Strategy and Corporate Development
Douglas W. Rau Vice President, Human Resources
Rakesh Sachdev Vice President, CFO and Secretary
Gerrit J. C. van den Dool Vice President, Sales
Steven G. Walton Vice President, Safety and Quality
Kirk A. Richter Vice President and Treasurer
Carl S. Turza Vice President and Chief Information Officer

Product lines

Sigma-Aldrich has a variety of product lines, each offered under separate branding.

Subsidiaries

Aldrich

The Aldrich Logo.

Aldrich is a supplier in the research and fine chemicals market. Aldrich provides organic and inorganic chemicals, building blocks, reagents, advanced materials and stable isotopes for chemical synthesis, medicinal chemistry and materials science. Aldrich's chemicals catalog, the "Aldrich Catalog and Handbook" is often used as a handbook due to the inclusion of structures, physical data, and literature references. Many students use it as a reference book, especially undergraduates, as it is offered free by request.

Sigma

The Sigma Logo.

Sigma is the Sigma-Aldrich's main biochemical supplier, with offerings including antibiotics, buffers, carbohydrates, enzymes, forensic tools, hematology and histology, nucleotides, proteins, peptides, amino acids and their derivatives.

Sigma RBI

The Sigma RBI Logo.

Sigma RBI produces specialized products for use in the field of cell signaling and neuroscience. Their offerings range from standard biochemical reagents to the latest cutting–edge research tools, including new ligands for receptors and ion channels, novel enzyme inhibitors, phosphospecific antibodies, key signal transduction enzymes, and assay kits for cell signaling.

ISOTEC

The ISOTEC Logo.

ISOTEC provides isotopically labeled products for protein structure determination, peptide synthesis, proteomics, metabolic research, magnetic resonance imaging, nuclear magnetic resonance, breath test substrates, agriculture, as well as gas and gas mixes.

Fluka

The Fluka Logo.

Fluka manufactures chemicals and reagents for analytical, organic and biochemical research, and intermediates for the chemical and pharmaceutical industries.

Riedel-de Haën

The Riedel-de Haën Logo.

Riedel-de Haën was incorporated with Sigma-Aldrich in 1999 and manufactures reagents and standards.

Supelco

The Supelco Logo.

Supelco is the chromotography products branch of Sigma-Aldrich. It provides chromatography columns and related tools for environmental, government, food and beverage, pharmaceutical, biotechnology, medical and chemical laboratories; sample preparation products and chemical reference standards.

Sigma-Aldrich Fine Chemicals

The SAFC Logo.

Sigma-Aldrich Fine Chemicals (SAFC) is the fine chemical supply branch of Sigma-Aldrich specializing in raw materials for cell culture products; customized services for raw materials, manufacturing of active pharmaceutical ingredients.

Sigma Life Science (formally Sigma-Genosys)

Sigma Life Science provides products such as custom DNA/RNA oligos; custom DNA and LNA probes; siRNA; isotopically-labelled peptides and peptide libraries.

Carbolabs

Carbolabs produces research quantities of chemicals produced by phosgenation reactions. The company was acquired in 1998[23].

See also

References

  1. ^ "Sigma-Aldrich Corporation - Investor Relations". http://investor.sigmaaldrich.com/. 
  2. ^ "Yahoo Finance Profile for Sigma-Aldrich Corporation". http://finance.yahoo.com/q/pr?s=SIAL. 
  3. ^ a b c d e f "History of Sigma-Aldrich". Aldrichimica Acta, vol. 34, no. 2, 2001, PDF pages 5-16. http://www.sigmaaldrich.com/etc/medialib/docs/Aldrich/Acta/al_acta34_2.pdf. 
  4. ^ Bader, Alfred (1995). Adventures of a Chemist Collector. London: Weidenfeld and Nicolson. p. 1-288. 
  5. ^ "Funding Universe History of Sigma-Aldrich Corporation". Funding-Universe. http://www.fundinguniverse.com/company-histories/SigmaAldrich-Corporation-Company-History.html. 
  6. ^ "Sigma-Aldrich Corp acquires Isotec Inc from Taiyo Nippon Sanso Corp". http://www.alacrastore.com/deal-snapshot/Sigma_Aldrich_Corp_acquires_Isotec_Inc_from_Taiyo_Nippon_Sanso_Corp-291771. 
  7. ^ "BiofInformatics, LLC: Life Science Marketing—Who’s on Top?". http://www.gene2drug.com/about/archives.asp?newsId=33. 
  8. ^ "Sigma-Aldrich Corp acquires Ultrafine". http://www.alacrastore.com/deal-snapshot/Sigma_Aldrich_Corp_acquires_Ultrafine-379839. 
  9. ^ "Sigma-Aldrich Corp acquires JRH Biosciences Inc from CSL Ltd". http://www.alacrastore.com/deal-snapshot/Sigma_Aldrich_Corp_acquires_JRH_Biosciences_Inc_from_CSL_Ltd-404688. 
  10. ^ "NCBI on Sigma-Aldrich". http://www.ncbi.nlm.nih.gov/projects/genome/probe/doc/DistrSigmaAldrich.shtml. 
  11. ^ "Sigma-Aldrich Corp acquires Beijing Superior Chem & Instr". http://www.alacrastore.com/deal-snapshot/Sigma_Aldrich_Corp_acquires_Beijing_Superior_Chem_Instr-446229. 
  12. ^ "Sigma-Aldrich Corp acquires Pharmorphix Ltd". http://www.alacrastore.com/deal-snapshot/Sigma_Aldrich_Corp_acquires_Pharmorphix_Ltd-453051. 
  13. ^ "Sigma-Aldrich Corp acquires Advanced Separation Tech Inc from Calgon Carbon Corp". http://www.alacrastore.com/deal-snapshot/Sigma_Aldrich_Corp_acquires_Advanced_Separation_Tech_Inc_from_Calgon_Carbon_Corp-457772. 
  14. ^ "Sigma-Aldrich Corp acquires Epichem Group Ltd". http://www.alacrastore.com/deal-snapshot/Sigma_Aldrich_Corp_acquires_Epichem_Group_Ltd-471452. 
  15. ^ "SEC Info - Sigma-Aldrich Corporation". http://www.secinfo.com/d14D5a.s181z.htm. 
  16. ^ "Hoover's Company Overview of Sigma-Aldrich Corporation". http://www.hoovers.com/sigma-aldrich/--ID__14717--/free-co-factsheet.xhtml. 
  17. ^ "Sigma-Aldrich Corporation Quarterly Report, May 2009". http://investor.sigmaaldrich.com/secfiling.cfm?filingID=1193125-09-99135. 
  18. ^ "SIAL". http://finance.yahoo.com/q/co?s=sial. 
  19. ^ "Omicron Biochemicals". http://www.omicronbio.com/. 
  20. ^ "Cambridge Isotope Laboratories, Inc.". http://www.isotope.com/cil/index.cfm?CFID=27170444&CFTOKEN=29582015. 
  21. ^ "Stable Isotope Biochemicals". ISIS. http://www.icis.com/Search/ProductNumber/123121/WorldWide/Stable+Isotope+Biochemicals.htm. 
  22. ^ "Sigma-Aldrich Investor Relations". http://investor.sigmaaldrich.com/management.cfm. 
  23. ^ "Carbolabs purchased". ICIS. http://www.icis.com/Articles/1998/06/01/60679/carbolabs-purchased.html. 

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