Sign of the Cross may refer to:
- Sign of the Cross, the ritual hand motion by bible-believers
- The Sign of the Cross: Travels in Catholic Europe, a book by Colm Tóibín
- The Sign of the Cross (play), 1895 play by Wilson Barrett
- The Sign of the Cross (film), directed by Cecil B. DeMille, based on the play
- "Sign of the Cross", a song by Iron Maiden on their album The X Factor
- "Sign of the Cross", a song by Avantasia
- "Sign of the Cross", a song by Terveet Kädet
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