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Silver sulfadiazine

 
Drug Info: Silver Sulfadiazine

Brand names: Silvadene®, SSD AF®, SSD®, Thermazene®

Chemical formula:



Silver Sulfadiazine Topical cream

What is this medicine?

SILVER SULFADIAZINE is a sulfonamide antibiotic. It is used on the skin for second or third degree burns. It helps to prevent or treat serious infection.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• anemia or other blood disorders
• glucose-6-phosphate dehydrogenase (G6PD) deficiency
• kidney disease
• liver disease
• porphyria
an unusual or allergic reaction to silver sulfadiazine, sulfa drugs, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

This medicine is for external use only. Follow the directions on the prescription label. Clean the affected area and remove burned or dead skin. Wear a sterile glove to apply the cream. Apply the cream to cover the whole area evenly. Treated areas can be left uncovered, but a gauze dressing may be used. Do not get this medicine in your eyes. If you do, rinse out with plenty of cool tap water. Finish the full course of medicine prescribed by your doctor or health care professional even if you think your condition is better. Do not stop using except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

• collagenase, papain, or sutilains

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Tell your doctor or health care professional if your skin condition does not begin to get better within 3 to 5 days.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
• fever, sore throat, chills
• increased sensitivity to the sun or ultraviolet light
• lower back pain
• pain or difficulty passing urine
• rash that appears or worsens following treatment, continued redness, swelling, burning, itching, stinging, or pain at the area of use
• redness, blistering, peeling or loosening of the skin
• unusual bleeding or bruising

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
• brownish gray discoloration of skin, nails or clothing
• itching

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

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Wikipedia: Silver sulfadiazine
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Silver sulfadiazine
Systematic (IUPAC) name
Silver [(4-aminophenyl)sulfonyl](pyrimidin-2-yl)azanide
Identifiers
CAS number 22199-08-2
ATC code D06BA01
PubChem 441244
Chemical data
Formula C10H9AgN4O2S 
Mol. mass 357.14 g/mol
SMILES eMolecules & PubChem
Synonyms (4-Amino-N-2-pyrimidinylbenzenesulfonamidato-NN,01)-silver, sulfadiazine silver, silver (I) sulfadiazine, 4-amino-N-(2-pyrimidinyl)benzenesulfonamide silver salt, dermazine, geben, silvadene
Physical data
Melt. point 285 °C (545 °F)
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion N/A
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes topical
 Yes check.svgY(what is this?)  (verify)

Silver sulfadiazine is a sulfa derivative[1] topical antibacterial historically used as a topical burn cream on second- and third-degree burns. It prevents the growth of a wide array of bacteria, as well as yeast, on the damaged skin. Studies however have found that it increased healing times and is therefore no longer recommended.[2]

Silver sulfadiazine is typically delivered in a 1% solution suspended in a water-soluble base. The chemical itself is poorly soluble, and has only very limited penetration through the skin. Only when applied to very large area burns is absorption into the body generally a problem.

Well-known proprietary brand names are Silvadene and Flamazine. The medication is also marketed under Kendall as Thermazene, with the aforementioned silvadene still functioning as a genericized trademark.

Possible side effects

See also

References

  1. ^ Fisher NM, Marsh E, Lazova R (October 2003). "Scar-localized argyria secondary to silver sulfadiazine cream". J. Am. Acad. Dermatol. 49 (4): 730–2. PMID 14512929. http://linkinghub.elsevier.com/retrieve/pii/S0190962202615749. 
  2. ^ Wasiak J, Cleland H, Campbell F (2008). "Dressings for superficial and partial thickness burns". Cochrane Database Syst Rev (4): CD002106. doi:10.1002/14651858.CD002106.pub3. PMID 18843629. 

 
 

 

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